ReviewJournal of clinical medicine2023
Management of Acute Cholecystitis in High-Risk Patients: Percutaneous Gallbladder Drainage as a Definitive Treatment vs. Emergency Cholecystectomy-Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Comparing percutaneous treatment and cholecystectomy outcomes in acute cholecystitis patients: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- Long-term outcomes of percutaneous transhepatic gallbladder drainage without cholecystectomy: impact of comorbidity and potential role of stone removal.Surgical endoscopy · 2026Article
- Preoperative predictors of difficult laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage in patients with cholecystitis.Clinics (Sao Paulo, Brazil) · 2026Article
- Safety and Feasibility of Early Laparoscopic Cholecystectomy in High-Risk Acute Cholecystitis: A Critical Evaluation of Tokyo Guidelines 2018 Risk Stratification.World journal of surgery · 2026Article
- Outcomes of acute moderate cholecystitis management techniques: percutaneous transhepatic gallbladder drainage and early laparoscopic cholecystectomy.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Observational
- Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Should the endoscopic option become the status quo?World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Management of Acute Cholecystitis in a Patient With Eisenmenger Syndrome and Abdominal Heterotaxy: A Case Report.The American journal of case reports · 2026Article
- Interventional management of acute perforated cholecystitis: When is percutaneous transhepatic cholecystostomy a reasonable therapeutic option?World journal of gastrointestinal surgery · 2026Article
- A 10-Year Study on Percutaneous Cholecystostomy for Acute Cholecystitis at a Tertiary Referral Hospital.Journal of clinical medicine · 2026Article
- Lateral approach in laparoscopic cholecystectomy for acute cholecystitis with stones: advantages in reducing inflammation, stress, and enhancing recovery.Frontiers in surgery · 2026Article
- Predictors of acute gangrenous cholecystitis and its complications: a retrospective cohort study.BMC surgery · 2025Article
- Cystic Duct Stenting Versus Other Treatment Modalities for the Management of Acute Cholecystitis in Patients with Decompensated Cirrhosis.Digestive diseases and sciences · 2025Article
- The influence of percutaneous cholecystostomy duration on optimizing surgical outcomes and timing of interval cholecystectomy in ASA II patients with grade II-III acute calculous cholecystitis.Langenbeck's archives of surgery · 2025Article
- Management of high-surgical-risk patients with acute cholecystitis following percutaneous cholecystostomy: results of an international Delphi consensus study.International journal of surgery (London, England) · 2025Article
- Application effect of standardized nursing process of abdominal drainage tube in cholelithiasis: a single-center retrospective cohort study.BMC gastroenterology · 2025Article
- COVID-19 infection is a significant risk factor for death in patients presenting with acute cholecystitis: a secondary analysis of the ChoCO-W cohort study.World journal of emergency surgery : WJES · 2025Review
- Review
- Clinical efficacy of laparoscopic cholecystectomy combined with percutaneous transhepatic gallbladder drainage in severe acute cholecystitis: an analysis of prognostic risk factors.Frontiers in surgery · 2025Article
- Effect of surgical timing on postoperative outcomes in patients with acute cholecystitis after delayed percutaneous transhepatic gallbladder drainage.World journal of gastrointestinal surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review aims to investigate whether percutaneous transhepatic gallbladder biliary drainage (PTGBD) is superior to emergency cholecystectomy (EC) as a definitive treatment in high-risk patients with acute cholecystitis (AC). MATERIAL AND
methodsA systematic literature search was performed until December 2022 using the Scopus, Medline/PubMed and Web of Science databases.
resultsSeventeen studies have been included with a total of 783,672 patients (32,634 treated with PTGBD vs. 4663 who underwent laparoscopic cholecystectomy, 343 who had open cholecystectomy and 746,032 who had some form of cholecystectomy, but without laparoscopic or open approach being specified). An analysis of the results shows that PTGBD, despite being less invasive, is not associated with lower morbidity with respect to EC (RR 0.77 95% CI [0.44 to 1.34]; I
conclusionsIn our systematic review, the majority of studies have very low-quality evidence and more RCTs are needed; furthermore, PTGBD is inferior in the treatment of AC in high-risk patients. The definition of high-risk patients is important in interpreting the results, but the methods of assessment and definitions differ between studies. The results of our systematic review and meta-analysis failed to demonstrate any advantage of using PTGBD over ER as a definitive treatment of AC in critically ill patients, which suggests that EC should be considered as the treatment of choice even in very high-risk patients. Most likely, the inferiority of PTGBD versus early LC for high-risk patients is related to an association of various patient-side factor conditions and the severity of acute cholecystitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.