ArticleAlzheimer's research & therapy2023
Network analysis of neuropsychiatric symptoms in Alzheimer's disease.
Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Integrative Transcriptomic and Interactome Analyses Prioritize Candidate Genes for Alzheimer's Disease.Molecular neurobiology · 2026Article
- Behavioral Complexity in Alzheimer's Disease: A Diversity-Based Analysis of Neuropsychiatric Symptoms.Brain sciences · 2026Article
- Stage-dependent reorganization of amyloid PET region-symptom bipartite networks in drug-naïve, amyloid-positive Alzheimer's disease.Translational psychiatry · 2026Article
- A Network Analysis of Panic Disorder, Agoraphobia, and Generalized Anxiety Disorder in 463 Patients From a Psychiatric Hospital.Brain and behavior · 2026Article
- Caregiver-Reported Behavioral Changes After Donepezil Transdermal Patch Therapy in Alzheimer's Disease: An Exploratory Real-World Network Analysis.Neuropsychiatric disease and treatment · 2026Article
- Identifying central behavioral and psychological symptoms associated with care time in older adults with dementia: a network analysis.Frontiers in public health · 2026Article
- Prevalence and clinical correlates of aggressive behavior in male inpatients with alcohol dependence during hospitalization.Frontiers in psychiatry · 2026Article
- Identification of the central symptoms of neuropsychiatric symptoms among older adults with mild cognitive impairment: a network analysis.Frontiers in psychiatry · 2026Article
- Classification of AD and bvFTD using neuropsychological and neuropsychiatric variables: a machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.Journal of neurology, neurosurgery, and psychiatry · 2025Article
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Abstract
backgroundNeuropsychiatric symptoms due to Alzheimer's disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms and methods of analysis are needed to identify effective treatment targets. The current investigation leveraged the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) to examine the network structure of neuropsychiatric symptoms among symptomatic older adults with cognitive impairment.
methodsThe network relationships of behavioral symptoms were estimated from Neuropsychiatric Inventory Questionnaire (NPI-Q) data acquired from 12,494 older adults with MCI and AD during their initial visit. Network analysis provides insight into the relationships among sets of symptoms and allows calculation of the strengths of the relationships. Nodes represented individual NPI-Q symptoms and edges represented the pairwise dependency between symptoms. Node centrality was calculated to determine the relative importance of each symptom in the network.
resultsThe analysis showed patterns of connectivity among the symptoms of the NPI-Q. The network (M = .28) consisted of mostly positive edges. The strongest edges connected nodes within symptom domain. Disinhibition and agitation/aggression were the most central symptoms in the network. Depression/dysphoria was the most frequently endorsed symptom, but it was not central in the network.
conclusionsNeuropsychiatric symptoms in MCI and AD are highly comorbid and mutually reinforcing. The presence of disinhibition and agitation/aggression yielded a higher probability of additional neuropsychiatric symptoms. Interventions targeting these symptoms may lead to greater neuropsychiatric symptom improvement overall. Future work will compare neuropsychiatric symptom networks across dementia etiologies, informant relationships, and ethnic/racial groups, and will explore the utility of network analysis as a means of interrogating treatment effects.
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