ArticleLipids in health and disease2023
The association between exposure to volatile organic compounds and serum lipids in the US adult population.
Article in Lipids in health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Associations between volatile organic compound mixtures and allostatic load: Evidence from the Green Heart Louisville Project.Environmental research · 2026Article
- Association between volatile organic compounds in urine and dyslipidemia: findings based on analysis of NHANES data.Lipids in health and disease · 2025Article
- Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011-2018.Scientific reports · 2025Article
- Article
- Harnessing serum VOCs and machine learning for the early detection of MAFLD.Frontiers in endocrinology · 2025Article
- Association between volatile organic compounds exposure and cardiometabolic function: a population-based study.Frontiers in public health · 2025Article
- Microbiomics and metabolomics explored the characteristics of gut microbiota and metabolites in patients with aortic dissection.Frontiers in cellular and infection microbiology · 2025Article
- Association between volatile organic compounds exposure and infertility risk among American women aged 18-45 years from NHANES 2013-2020.Scientific reports · 2024Article
- Development and Validation of a Clinical Predictive Nomogram for Assessing the Risk of Recurrence of Acute Pancreatitis in Combined Hypertriglyceridemia.Digestive diseases and sciences · 2024Article
- Associations of exposure to volatile organic compounds with sleep health and potential mediators: analysis of NHANES data.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimEpidemiological evidence on the relationship between exposure to volatile organic compounds (VOCs), both single and mixed, and serum lipid levels is limited, and their relationship remains unclear. Our study aimed to investigate the associations of exposure to VOCs with serum lipid levels in the US adult population. METHODS AND
resultsThe study examined the association of 16 VOC levels (2-methylhippuric acid, 3- and 4-methylhippuric acid, N-acetyl-S-(2-carbamoylethyl)-L-cysteine, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine, 2-aminothiazoline-4-carboxylic acid, N-acetyl-S-(benzyl)-L-cysteine, N-acetyl-S-(n-propyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine, N-acetyl-S-(2-cyanoethyl)-L-cysteine, N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine, N-acetyl-S-(2-hydroxypropyl)-L-cysteine. N-Acetyl-S-(3-hydroxypropyl)-L-cysteine, mandelic acid, N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine, phenylglyoxylic acid and N-acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine) with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) using data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2015, and a total of 1410 adults were enrolled. The association was evaluated by Bayesian kernel machine regression (BKMR), multiple linear regression and weighted quantile sum (WQS) regression. In BKMR analysis, exposure to VOCs is positively correlated with levels of TC, TG, and LDL-C. However, statistical significance was observed only for the impact on TG. Our linear regression analysis and WQS regression generally support the BKMR results. Several VOCs were positively associated with serum lipid profiles (e.g., the ln-transformed level of mandelic acid (MA) displayed an increase in estimated changes of 7.01 (95% CIs: 2.78, 11.24) mg/dL for TC level), even after the effective number of tests for multiple testing (P < 0.05).
conclusionsExposure to VOCs was associated with serum lipids, and more studies are needed to confirm these findings.
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