ArticleLa Radiologia medica2023
Ultrasound-derived fat fraction for detection of hepatic steatosis and quantification of liver fat content.
Article in La Radiologia medica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Ultrasound-derived fat fraction for diagnosing hepatic steatosis: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Diagnostic performance of ultrasound-derived fat fraction for detecting hepatic steatosis in patients with tumor-related liver disease.Abdominal radiology (New York) · 2026Article
- Quantitative liver ultrasound: current status and challenges.Ultrasonography (Seoul, Korea) · 2026Article
- Quantitative ultrasound-derived fat fraction for hepatic steatosis in MASLD using liver biopsy as the reference standard: a dual-center study.European radiology · 2026Article
- Is ultrasonic speed of sound estimation for liver fat quantification affected by measurement depth?Abdominal radiology (New York) · 2026Article
- Ultrasound-Derived Fat Fraction and Metabolic Parameters in Predicting Panvascular Disease Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients: A Prospective Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Correlation of ultrasound attenuation with proton density fat fraction across multiple organs in healthy volunteers.Medical physics · 2026Article
- Ultrasonic radio frequency signals-based hepatorenal index improved the diagnostic performance in steatotic liver disease.Abdominal radiology (New York) · 2026Article
- Thermoacoustic Ultrasound Assessment of Liver Steatosis-A Novel Approach for MASLD Diagnosis.Diagnostics (Basel, Switzerland) · 2026Article
- Efficacy evaluation of ultrasound-derived fat fraction in predicting of the severity of women with polycystic ovary syndrome and obesity.Frontiers in medicine · 2026Article
- Comparison of ultrasound-derived fat fraction and hepatorenal index for quantitative detection of hepatic steatosis: a multicenter MRI-PDFF-referenced study.Frontiers in nutrition · 2026Article
- Diagnostic performance of ultrasound-derived fat fraction for assessing steatotic liver disease with histopathology as the reference.Ultrasonography (Seoul, Korea) · 2026Article
- Trimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies.Quantitative imaging in medicine and surgery · 2026Article
- Artificial intelligence applications for managing metabolic dysfunction-associated steatotic liver disease: Current status and future prospects.World journal of gastroenterology · 2025Review
- Multiparametric Quantitative Ultrasound for Hepatic Steatosis: Comparison with CAP and Robustness Across Breathing States.Diagnostics (Basel, Switzerland) · 2025Article
- Prospective multicenter study on the reproducibility of ultrasound-derived fat fraction in assessing hepatic steatosis.Insights into imaging · 2025Article
- Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study.Pediatric radiology · 2025Article
- Ultrasound-derived fat fraction for the noninvasive quantification of hepatic steatosis: a prospective multicenter study.Insights into imaging · 2025Article
- Quantitative Ultrasound for Hepatic Steatosis: A Systematic Review Highlighting the Diagnostic Performance of Ultrasound-Derived Fat Fraction.Diagnostics (Basel, Switzerland) · 2025Review
- Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations.BMC medical imaging · 2025Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare ultrasound (US) and US-derived fat fraction (UDFF) with magnetic resonance proton density fat fraction (MRI-PDFF) for the detection of hepatic steatosis and quantification of liver fat content. MATERIALS AND
methodsBetween October and December 2022, 149 patients scheduled for an abdominal MRI agreed to participate in this study and underwent MRI-PDFF, US and UDFF. Inclusion criteria were: (a) no chronic liver disease or jaundice; (b) no MRI motion artifacts; (c) adequate liver examination at US. Exclusion criteria were: (a) alcohol abuse, chronic hepatitis, cirrhosis, or jaundice; (b) MRI artifacts or insufficient US examination. The median of 10 MRI-PDFF and UDFF measurements in the right hepatic lobe was analyzed. UDFF and MRI-PDFF were compared by Bland-Altman difference plot and Pearson's test. Sensitivity, specificity, positive and negative predictive values, accuracy, and area under the receiver-operator curve (AUC-ROC) of US and UDFF were calculated using an MRI-PDFF cut-off value of 5%. p values ≤ 0.05 were statistically significant.
results122 patients were included (61 men, mean age 60 years, standard deviation 15 years). The median MRI-PDFF value was 4.1% (interquartile range 2.9-6); 37.7% patients had a median MRI-PDFF value ≥ 5%. UDFF and MRI-PDFF had high agreement (p = 0.11) and positive correlation (⍴ = 0.81, p < 0.001). UDFF had a higher diagnostic value than US for the detection of steatosis, with AUC-ROCs of 0.75 (95% CI 0.65, 0.84) and 0.53 (95% CI 0.42, 0.64), respectively.
conclusionsUDFF reliably quantifies liver fat content and improves the diagnostic value of US for the detection of hepatic steatosis.
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