Evidence map›Paper›PMID 37567949›Full record

ArticleNPJ digital medicine2023

Blood glucose variance measured by continuous glucose monitors across the menstrual cycle.

Georgianna Lin, Rumsha Siddiqui, Zixiong Lin, Joanna M Blodgett, Shwetak N Patel, Khai N Truong, Alex Mariakakis

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06375577 nacompletednot on this mapstarted 2024, after this paper: background citation

Evaluating the Speed of Carbohydrate Supplement Absorption in an Athletic Population

TypeinterventionalSponsorLancaster UniversityRan2024 to 2024Enrolled16ConditionsHealthy, Nutrition, HealthyArms45 grams Voom Pocket Rocket Electro Energy, 45 grams SIS Go Isotonic Energy Gel, 45 grams Maurten Gel 160
NCT06638190 nacompletednot on this mapstarted 2024, after this paper: background citation

Role of the Fruit Matrix on the Absorption of Glucose From Orange Juice in Humans

TypeinterventionalSponsorMaría-Teresa García-ConesaRan2024 to 2025Enrolled25ConditionsHealthy NutritionArms100% Orange juice, 50% Orange juice, 0% Orange juice, Glucose, 100% Orange juice Rep
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Journal of bacteriology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Are there sex differences in the variability of fasting metabolism?Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  13. Article
  14. Impact of Physiological Fluctuations of Sex Hormones During the Menstrual Cycle on Glucose Metabolism and the Gut Microbiota.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024
    Review
  15. Article
  16. Review
  17. 17β-Estradiol Effects in Skeletal Muscle: ADiagnostics (Basel, Switzerland) · 2024
    Article
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Georgianna LinUniversity of Toronto, Computer Science, Toronto, ON, Canada. blue.lin@mail.utoronto.ca.ORCID http://orcid.org/0000-0002-9993-2718
Rumsha SiddiquiQueen's University, Medicine, Kingston, ON, Canada.
Zixiong LinUniversity of Toronto, Computer Science, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-7958-590X
Joanna M BlodgettUniversity College London, Institute of Sport Exercise & Health, London, UK.ORCID http://orcid.org/0000-0001-7684-3571
Shwetak N PatelUniversity of Washington, Computer Science & Engineering, Seattle, WA, USA.
Khai N TruongUniversity of Toronto, Computer Science, Toronto, ON, Canada.
Alex MariakakisUniversity of Toronto, Computer Science, Toronto, ON, Canada.
University of Toronto · CAEnglish Institute of Sport · GBQueen's University · CAUniversity of Washington · US

Funding

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN-2021-03457Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN-2021-04268
6 · The paper itself

Abstract

Past studies on how blood glucose levels vary across the menstrual cycle have largely shown inconsistent results based on limited blood draws. In this study, 49 individuals wore a Dexcom G6 continuous glucose monitor and a Fitbit Sense smartwatch while measuring their menstrual hormones and self-reporting characteristics of their menstrual cycles daily. The average duration of participation was 79.3 ± 21.2 days, leading to a total of 149 cycles and 554 phases in our dataset. We use periodic restricted cubic splines to evaluate the relationship between blood glucose and the menstrual cycle, after which we assess phase-based changes in daily median glucose level and associated physiological parameters using mixed-effects models. Results indicate that daily median glucose levels increase and decrease in a biphasic pattern, with maximum levels occurring during the luteal phase and minimum levels occurring during the late-follicular phase. These trends are robust to adjustments for participant characteristics (e.g., age, BMI, weight) and self-reported menstrual experiences (e.g., food cravings, bloating, fatigue). We identify negative associations between each of daily estrogen level, step count, and low degrees of fatigue with higher median glucose levels. Conversely, we find positive associations between higher food cravings and higher median glucose levels. This study suggests that blood glucose could be an important parameter for understanding menstrual health, prompting further investigation into how the menstrual cycle influences glucose fluctuation.

Identifiers

PMID37567949
PMCPMC10421863
OpenAlexW4385762225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.