Evidence map›Paper›PMID 37567786›Full record

ArticleRNA (New York, N.Y.)2023

Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of

Olga V Hunter, Julio C Ruiz, Juliana N Flaherty, Nicholas K Conrad

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mechanisms and rationales of SAM homeostasis.Trends in biochemical sciences · 2025
    Review
  6. METTL Family in Healthy and Disease.Molecular biomedicine · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Olga V Hunter *Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Julio C Ruiz *Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Juliana N Flaherty *Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Nicholas K ConradDepartment of Microbiology, UT Southwestern Medical Center, Dallas, Texas 75390, USA Nicholas.conrad@utsouthwestern.edu.
Southwestern Medical Center · US

Funding

Mechanisms of KSHV posttranscriptional gene regulationR01AI123165 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CONRAD, NICHOLAS K · 2016 to 2025
$4.5M
Mechanisms of posttranscriptional regulation of SAM homeostasisR01GM127311 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CONRAD, NICHOLAS K · 2019 to 2022
$1.4M
NIAID NIH HHS R01 AI123165NIGMS NIH HHS R01 GM127311
6 · The paper itself

Abstract

S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events, so cells need to carefully control SAM levels.

Indexed as

AdenosineGene Expression Regulation3' Untranslated RegionsChromosomal Proteins, Non-HistoneHumansMethionine AdenosyltransferaseMethylationMethyltransferasesRNA, MessengerS-Adenosylmethionine3' Untranslated RegionsAdenosineChromosomal Proteins, Non-HistoneMAT2A protein, humanMethionine AdenosyltransferaseMethyltransferasesMETTL16 protein, humanRNA, MessengerS-Adenosylmethionineintron detentionMAT2AMETTL16mRNA stabilitySAM homeostasis

Identifiers

PMID37567786
PMCPMC10578476
OpenAlexW4385754243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.