SynthesisOpen heart2023
Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis.
Synthesis in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- Geriatric Assessment in Patients Aged 70 Years and Older Considered for CAR T-Cell Therapy: A Retrospective Study.Cancers · 2026Article
- Dysphagia: A Novel Risk Factor for Poor Outcomes Following Cardiovascular Procedures.Journal of the American Heart Association · 2026Article
- Association between frailty and long-term outcomes in patients undergoing TAVI admitted to private intensive care units in Australia.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Article
- Impact of Preoperative Malnutrition and Sarcopenia on Clinical Outcomes After Transcatheter Aortic Valve Replacement.Circulation reports · 2026Article
- Frailty as a predictor of delayed discharge and 12-month mortality following transcatheter aortic valve implantation.Journal of geriatric cardiology : JGC · 2026Article
- Review
- Superiority of the Rockwood Clinical Frailty Scale for Assessing Long-Term Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Impact of Frailty Risk on Adverse Outcomes after Open Heart Valve Surgery in Older Patients: A Retrospective Cohort Study.Progress in rehabilitation medicine · 2026Article
- Mortality following glaucoma surgery in octogenarians with primary open angle glaucoma.International ophthalmology · 2025Article
- Objective analysis of frailty-based 10-year outcomes of transcatheter and surgical aortic valve replacement.JTCVS structural and endovascular · 2025Article
- Prognostic Role of the Modified Frailty Index in Octogenarians Undergoing Minimally Invasive Aortic Valve Replacement.Journal of clinical medicine · 2025Article
- Prognostic value of frailty across age groups in emergency department patients aged 65 and above.BMC geriatrics · 2025Article
- Periprocedural care for frail older patients with aortic stenosis undergoing transcatheter aortic valve replacement.International journal of cardiology. Heart & vasculature · 2025Review
- Article
- Clinical Impact of Baseline Frailty Status and Residual Mitral Regurgitation After Transcatheter Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry.Journal of the American Heart Association · 2024Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAssessment of frailty prior to aortic valve intervention is recommended in European and North American valvular heart disease guidelines. However, there is a lack of consensus on how it is best measured. The Clinical Frailty Scale (CFS) is a well-validated measure of frailty that is relatively quick to calculate. This meta-analysis sought to examine whether the CFS predicts mortality and morbidity following either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR).
methodsNine electronic databases were searched systematically for data on clinical outcomes post-TAVI/SAVR, where patients had undergone preoperative frailty assessment using the CFS. The primary endpoint was 12-month mortality. TAVI and SAVR data were assessed and reported separately. For each individual study, the incidence of adverse outcomes was extracted according to a CFS score of 5-9 (ie, frail) versus 1-4 (ie, non-frail), with meta-analysis performed using a random effects model.
resultsOf 2612 records screened, nine were included in the review (five TAVI, three SAVR and one which included both interventions). Among 4923 TAVI patients, meta-analysis showed 12-month mortality rates of 19.1% for the frail cohort versus 9.8% for the non-frail cohort (RR 2.53 (1.63 to 3.95), p<0.001, I
conclusionsFrailty, as determined by the CFS, was associated with an increased mortality risk in the 12 months following either TAVI or SAVR. These data would support its use in the preoperative assessment of elderly patients undergoing aortic valve interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.