Evidence map›Paper›PMID 37566734›Full record

ArticleACS chemical neuroscience2023

Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the

Michael P D'Erasmo, Nicholas S Akins, Peipei Ma, Yao Jing, Sharon A Swanger, Savita K Sharma, Perry W Bartsch, David S Menaldino, Paul J Arcoria, Thi-Thien Bui and 17 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 3 institutions in 2 countries.

Michael P D'ErasmoDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Nicholas S AkinsDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0001-8846-3349
Peipei MaDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Yao JingDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Sharon A SwangerDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Savita K SharmaDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Perry W BartschDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
David S MenaldinoDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Paul J ArcoriaDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Thi-Thien BuiINMED, INSERM, Aix Marseille University, 13284 Marseille, France.
Alexandre Pons-BennaceurINMED, INSERM, Aix Marseille University, 13284 Marseille, France.
Phuong LeDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
James P AllenDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Elijah Z UllmanDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Kelsey A NocillaDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Jing ZhangDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Riley E PerszykDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Sukhan KimDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Timothy M AckerDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Azmain TazDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Samantha L BurtonDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Kevin CoeJanssen Research & Development, LLC, San Diego, California 92121, United States.ORCID 0000-0002-8162-1559
Russell G FritzemeierDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Nail BurnashevINMED, INSERM, Aix Marseille University, 13284 Marseille, France.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.
Dennis C LiottaDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7736-7113
Stephen F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-3750-9615
Emory University · USInserm · FRJanssen (United States) · US

Funding

Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted TherapyR01HD082373 · NICHD · EMORY UNIVERSITY · PI YUAN, HONGJIE · 2015 to 2025
$3.3M
Subtype-selective NMDA ligands for Alzheimer's DiseaseR01AG075444 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2022 to 2025
$3.1M
Glycogen synthase kinase 3 ligand discovery for Alzheimer’s diseaseRF1AG081401 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2023 to 2023
$2.3M
Subtype-selective phosphodiesterase PET ligandsR01AG079956 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2023 to 2025
$2.3M
Molecular and functional diversity of NMDA receptors in the thalamusR01NS105804 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SWANGER, SHARON ANN · 2019 to 2023
$1.7M
Defining native glutamate receptor diversityR21NS128635 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SWANGER, SHARON ANN · 2022 to 2022
$456k
NIA NIH HHS R01 AG075444NIA NIH HHS R01 AG079956NIA NIH HHS RF1 AG081401NICHD NIH HHS R01 HD082373NINDS NIH HHS R01 NS105804NINDS NIH HHS R21 NS128635NINDS NIH HHS R35 NS111619
6 · The paper itself

Abstract

Subunit-selective inhibition of

Indexed as

Receptors, N-Methyl-D-AspartateSynaptic TransmissionAnimalsBrainGlutamic AcidMiceStructure-Activity RelationshipGlutamic AcidReceptors, N-Methyl-D-Aspartateblood–brain barrierepilepsyNR2CNR2Dseizuretuberous sclerosis complex

Identifiers

PMID37566734
PMCPMC10485906
OpenAlexW4385753734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.