Evidence map›Paper›PMID 37566701›Full record

ArticleThe journal of physical chemistry. B2023

Diffusion Resistance of Segmented Channels.

Leonardo Dagdug, Alexander M Berezhkovskii, Sergey M Bezrukov

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leonardo DagdugDepartamento de Fisica, Universidad Autonoma Metropolitana-Iztapalapa, 09340 Mexico City, Mexico.
Alexander M BerezhkovskiiSection of Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20819, United States.ORCID 0000-0002-0564-0408
Sergey M BezrukovSection of Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20819, United States.ORCID 0000-0002-8209-8050

Funding

Biophysics of Large Membrane ChannelsZIAHD000072 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BEZRUKOV, SERGEY M · 2009 to 2025
$22.8M
Intramural NIH HHS ZIA HD000072
6 · The paper itself

Abstract

The geometry of ion and metabolite channels in membranes of biological cells and organelles is usually far from that of a regular right cylinder. Rather, the channels have complex shapes that are characterized by the so-called vestibules and constriction zones which play roles of molecular filters determining the channel selectivity. In the present paper we discuss several channel structures with varying radius that approximate most of the cases found in nature, specifically, channels of smoothly varying radius and channels composed of multiple cylindrical sections of different lengths and radii including channels containing very thin circular constrictions. We consider diffusive transport of electrically neutral molecules driven by the concentration gradient and derive analytical expressions for the diffusion resistance - the integral parameter that describes steady-state transport properties of membrane channels.

Identifiers

PMID37566701
PMCPMC13548823

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.