Evidence map›Paper›PMID 37566656›Full record

ArticleScience advances2023

Emergent mechanical control of vascular morphogenesis.

Jordan Whisler, Somayeh Shahreza, Karin Schlegelmilch, Nil Ege, Yousef Javanmardi, Andrea Malandrino, Ayushi Agrawal, Alessandro Fantin, Bianca Serwinski, Hesham Azizgolshani and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Mechanical signatures in cancer metastasis.npj biological physics and mechanics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 8 institutions in 4 countries.

Jordan WhislerDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0009-1078-173X
Somayeh ShahrezaDepartment of Mechanical Engineering, University College London, London, UK.ORCID 0000-0002-4604-2068
Karin SchlegelmilchTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-3173-0914
Nil EgeTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-3441-3706
Yousef JavanmardiDepartment of Mechanical Engineering, University College London, London, UK.ORCID 0000-0002-7260-8395
Andrea MalandrinoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ayushi AgrawalDepartment of Mechanical Engineering, University College London, London, UK.ORCID 0000-0001-5428-5142
Alessandro FantinUCL Institute of Ophthalmology, University College London, London, UK.ORCID 0000-0002-5517-6068
Bianca SerwinskiDepartment of Mechanical Engineering, University College London, London, UK.
Hesham AzizgolshaniDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Clara ParkDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1833-9822
Victoria ShoneExperimental Histopathology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-2764-153X
Olukunle O DemurenDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Amanda Del RosarioDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6107-7149
Vincent L ButtyDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1173-2429
Natalie HolroydUCL Centre for Advanced Biomedical Imaging, Paul O'Gorman Building, 72 Huntley Street, London, UK.ORCID 0000-0001-9174-1346
Marie-Charlotte DomartElectron Microscopy Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-5703-2922
Steven HooperTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.
Nicolas SzitaDepartment of Biochemical Engineering, University College London, London, UK.
Laurie A BoyerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-3491-4962
Simon Walker-SamuelUCL Centre for Advanced Biomedical Imaging, Paul O'Gorman Building, 72 Huntley Street, London, UK.ORCID 0000-0003-3530-9166
Boris DjordjevicDepartment of Mechanical Engineering, University College London, London, UK.
Graham K SheridanSchool of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-8493-2651
Lucy CollinsonElectron Microscopy Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-0260-613X
Fernando CalvoInstituto de Biomedicina y Biotecnología de Cantabria (Consejo Superior de Investigaciones Científicas, Universidad de Cantabria), Santander, Spain.
Christiana RuhrbergUCL Institute of Ophthalmology, University College London, London, UK.ORCID 0000-0002-3212-9381
Erik SahaiTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-3932-5086
Roger KammDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-7232-304X
Emad MoeendarbaryDepartment of Mechanical Engineering, University College London, London, UK.ORCID 0000-0002-7019-3907
Massachusetts Institute of Technology · USThe Francis Crick Institute · GBUniversity College London · GBWildfowl & Wetlands Trust · GBAdvanced Imaging Research (United States) · USUniversidad de Cantabria · ESUniversity of Milan · ITUniversity of Nottingham · GB

Funding

Wellcome Trust FC001003Wellcome Trust FC001144
6 · The paper itself

Abstract

Vascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, and shape change to sculpt the developing vascular network. However, it remains unclear whether developing vasculature actively regulates its own mechanical properties to achieve effective vascularization. We engineered tissue constructs containing endothelial cells and fibroblasts to investigate the mechanics of vascularization. Tissue stiffness increases during vascular morphogenesis resulting from emergent interactions between endothelial cells, fibroblasts, and ECM and correlates with enhanced vascular function. Contractile cellular forces are key to emergent tissue stiffening and synergize with ECM mechanical properties to modulate the mechanics of vascularization. Emergent tissue stiffening and vascular function rely on mechanotransduction signaling within fibroblasts, mediated by YAP1. Mouse embryos lacking YAP1 in fibroblasts exhibit both reduced tissue stiffness and develop lethal vascular defects. Translating our findings through biology-inspired vascular tissue engineering approaches will have substantial implications in regenerative medicine.

Indexed as

Endothelial CellsMechanotransduction, CellularAnimalsCell DifferentiationExtracellular MatrixMiceMorphogenesisTissue Engineering

Identifiers

PMID37566656
PMCPMC10421067
OpenAlexW4385754227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.