ArticleScience advances2023
Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.Science advances · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Astrocyte Mitochondrial UCP4 Reprograms Neuronal Network Oscillations via GDNF-Dependent KCells · 2026Article
- Altered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction.Molecular psychiatry · 2026Article
- Time-Dependent Therapeutic Effect of S-Ketamine on PTSD Mediated by VTA-OFC Dopaminergic Neurocircuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic pain.bioRxiv : the preprint server for biology · 2025Article
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
- Fiber Photometry Analysis of Spontaneous Dopamine Signals: TheACS chemical neuroscience · 2025Article
- A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety.The Journal of clinical investigation · 2025Article
- Kappa opioid receptors diminish spontaneous dopamine signals in awake mice through multiple mechanisms.Neuropharmacology · 2025Article
- Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing.bioRxiv : the preprint server for biology · 2025Article
- Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety.Science advances · 2025Article
- Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models.Genomic psychiatry : advancing science from genes to society · 2025Article
- Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.eLife · 2025Article
- The molecular clock drives motivated locomotion and time-of-day-dependent firing patterns in mouse dopaminergic neurons.Npj biological timing and sleep · 2025Article
- VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction.Nature communications · 2024Article
- Article
- Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine is broadly implicated in reinforcement learning, but how patterns of dopamine activity are generated is poorly resolved. Here, we demonstrate that two ion channels, Kv4.3 and BKCa1.1, regulate the pattern of dopamine neuron firing and dopamine release on different time scales to influence separate phases of reinforced behavior in mice. Inactivation of Kv4.3 in VTA dopamine neurons increases ex vivo pacemaker activity and excitability that is associated with increased in vivo firing rate and ramping dynamics before lever press in a learned instrumental paradigm. Loss of Kv4.3 enhances performance of the learned response and facilitates extinction. In contrast, loss of BKCa1.1 increases burst firing and phasic dopamine release that enhances learning of an instrumental response and enhances extinction burst lever pressing in early extinction that is associated with a greater change in activity between reinforced and unreinforced actions. These data demonstrate that disruption of intrinsic regulators of neuronal activity differentially affects dopamine dynamics during reinforcement and extinction learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.