ArticlePLoS pathogens2023
Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance.
Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A genome-wide survey reveals that a diverse array of enhancers coordinates theGenome research · 2026Article
- Feasibility of a rat femoral-defect model for immediate perioperative and delayed post-implantation implant-associated bone infections.Journal of bone and joint infection · 2026Article
- Article
- Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses.PLoS pathogens · 2025Article
- The ghost of infections past: Accounting for heterogeneity in individual infection history improves accuracy in epidemic forecasting.PLoS biology · 2025Article
- Age-Dependent Immune Defense AgainstJournal of fungi (Basel, Switzerland) · 2025Article
- Current insights into insect immune memory.eLife · 2025Review
- Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae.Proceedings. Biological sciences · 2025Article
- Evolution of resistance and disease tolerance mechanisms to oral bacterial infection inOpen biology · 2025Article
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Transiently restricting individual amino acids protectsOpen biology · 2024Article
- IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission.PLoS pathogens · 2024Article
- A specific innate immune response silences the virulence of Pseudomonas aeruginosa in a latent infection model in the Drosophila melanogaster host.PLoS pathogens · 2024Article
- Coevolution of Age-Structured Tolerance and Virulence.Bulletin of mathematical biology · 2024Article
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- Granulocyte dynamics: a key player in the immune priming effects of crickets.Frontiers in immunology · 2024Article
- Disentangling specific and unspecific components of innate immune memory in a copepod-tapeworm system.Frontiers in immunology · 2024Article
- Professional phagocytes are recruited for the clearance of obsolete nonprofessional phagocytes in theFrontiers in immunology · 2024Article
- Role of gut commensal bacteria in juvenile developmental growth of the host: insights fromAnimal cells and systems · 2023Review
- Review
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5 authors.
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Abstract
Innate immune priming increases an organism's survival of a second infection after an initial, non-lethal infection. We used Drosophila melanogaster and an insect-derived strain of Enterococcus faecalis to study transcriptional control of priming. In contrast to other pathogens, the enhanced survival in primed animals does not correlate with decreased E. faecalis load. Further analysis shows that primed organisms tolerate, rather than resist infection. Using RNA-seq of immune tissues, we found many genes were upregulated in only primed flies, suggesting a distinct transcriptional program in response to initial and secondary infections. In contrast, few genes continuously express throughout the experiment or more efficiently re-activate upon reinfection. Priming experiments in immune deficient mutants revealed Imd is largely dispensable for responding to a single infection but needed to fully prime. Together, this indicates the fly's innate immune response is plastic-differing in immune strategy, transcriptional program, and pathway use depending on infection history.
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