ArticlePlant molecular biology2023
miR397-LACs mediated cadmium stress tolerance in Arabidopsis thaliana.
Article in Plant molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic and epigenetic mechanisms underlying cadmium (Cd) stress responses in soybean cultivars.Plant cell reports · 2026Article
- Physiological and Transcriptomic Analysis of Bread Wheat MicroRNAs in Response to Zinc Availability.Biomolecules · 2026Article
- MicroRNA-mediated regulation of cell wall dynamics and intercellular communication under stress.Frontiers in plant science · 2026Review
- Cell Wall-Based Machine Learning Models to Predict Plant Growth Using Onion Epidermis.International journal of molecular sciences · 2025Article
- MicroRNA gatekeepers: Orchestrating rhizospheric dynamics.Journal of integrative plant biology · 2025Review
- Transcriptome and MicroRNA Analysis ofInternational journal of molecular sciences · 2025Article
- Bioinformatic Enrichment and Network Analyses of miRNA-Related High-Throughput Sequencing Data.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genome-Wide Identification and Analysis of Phospholipase C Gene Family Reveals Orthologs, Co-Expression Networks, and Expression Profiling Under Abiotic Stress inPlants (Basel, Switzerland) · 2024Article
- Article
- TheHorticulture research · 2024Article
- microRNAs: Key Regulators in Plant Responses to Abiotic and Biotic Stresses via Endogenous and Cross-Kingdom Mechanisms.International journal of molecular sciences · 2024Review
- Advances in epigenetic studies of plant cadmium stress.Frontiers in plant science · 2024Review
- Dynamics and mechanics of plant cell walls: insights into plant growth, defence, and stress response.Plant molecular biology · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a non-essential heavy metal, assimilated in plant tissue with other nutrients, disturbing the ions' homeostasis in plants. The plant develops different mechanisms to tolerate the hazardous environmental effects of Cd. Recently studies found different miRNAs that are involved in Cd stress. In the current study, miR397 mutant lines were constructed to explore the molecular mechanisms of miR397 underlying Cd tolerance. Compared with the genetically modified line of overexpressed miR397 (artificial miR397, amiR397), the lines of downregulated miR397 (Short Tandem Target Mimic miR397, STTM miR397) showed more substantial Cd tolerance with higher chlorophyll a & b, carotenoid and lignin content. ICP-OES revealed higher cell wall Cd and low total Cd levels in STTM miR397 than in the wild-type and amiR397 plants.Further, the STTM plants produced fewer reactive oxygen species (ROS) and lower activity of antioxidants enzymes (e.g., catalase [CAT], malondialdehyde [MDA]) compared with amiR397 and wild-type plants after stress, indicating that silencing the expression of miR397 can reduce oxidative damage. In addition, the different family transporters' gene expression was much higher in the amiR397 plants than in the wild type and STTM miRNA397. Our results suggest that miR397 plays a role in Cd tolerance in Arabidopsis thaliana. Overexpression of miR397 could decrease Cd tolerance in plants by regulating the expression of LAC 2/4/17, changing the lignin content, which may play an important role in inducing different stress-tolerant mechanisms and protecting the cell from a hazardous condition. This study provides a basis to elucidate the functions of miR397 and the Cd stress tolerance mechanism in Arabidopsis thaliana.
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