Evidence map›Paper›PMID 37566167›Full record

ArticleAAPS PharmSciTech2023

Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil Fumarate.

Canberk Kayalar, Ziyaur Rahman, Eman M Mohamed, Sathish Dharani, Tahir Khuroo, Nada Helal, Mathew A Kuttolamadom, Mansoor A Khan

Open access · greenAbstract read
In one paragraph

Article in AAPS PharmSciTech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Canberk KayalarReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Ziyaur RahmanReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Eman M MohamedReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Sathish DharaniReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Tahir KhurooReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Nada HelalReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA.
Mathew A KuttolamadomDepartment of Engineering Technology & Industrial Distribution, College of Engineering, Texas A&M University, College Station, Texas, 77843, USA.
Mansoor A KhanReynolds Medical Sciences Building, Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Suite 159, College Station, Texas, 77843-1114, USA. mkhan@tamu.edu.ORCID http://orcid.org/0000-0003-3649-3874
Texas A&M Health Science Center · USTexas A&M University · US

Funding

Dose Flexible Combination 3D-Printed Delivery Systems for Antiviral Therapy in ChildrenR01HD112077 · NICHD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MANSOOR A KHAN, Ziyaur Rahman · 2023 to 2026
$2.2M
Age-appropriate flexible pediatric drug delivery systemsR56HD106612 · NICHD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI KHAN, MANSOOR A · 2021 to 2022
$677k
NICHD NIH HHS R01 HD112077NICHD NIH HHS R56 HD106612
6 · The paper itself

Abstract

The aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to obtain a consistent quality of printlets with desired properties, it is important to understand certain critical quality attributes for their main and interactions effect. The printlets were optimized by Box-Behnken's design of the experiment by varying process variables while keeping the composition constant. The composition contained 16.3% TDF, 72.7% polyvinyl pyrrolidone K16-18, 8% magnesium aluminum silicate, 3% Candurin

Indexed as

Antiviral AgentsPrinting, Three-DimensionalAnimalsDrug CompoundingRatsTenofovirTherapeutic EquivalencyAntiviral AgentsTenofovirAmorphousBioequivalenceCritical quality attributesPharmacokineticSelective laser sinteringTenofovir disoproxil fumarate

Identifiers

PMID37566167
PMCPMC12047738
OpenAlexW4385751778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.