ArticlePediatric nephrology (Berlin, Germany)2024
Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis.
Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Cardiopulmonary fitness in children/adolescents with chronic kidney disease and the impact of exercise training: a systematic review and meta-analysis of observational study and randomized controlled trials.Annals of medicine · 2025Pooled it
- Neurocognitive and Motor Performance in Pediatric Kidney Transplant Recipients: A Cross-Sectional Controlled Study.Children (Basel, Switzerland) · 2026Article
- Perspective Review: Advancing toward the diagnosis of sarcopenia in the pediatric population.Pediatric research · 2026Review
- Pathophysiology and potential treatment of uremic sarcopenia.Kidney research and clinical practice · 2026Article
- Balance in children with chronic kidney disease: the relationship between skeletal muscle mass index, fatigue, and physical function.Pediatric nephrology (Berlin, Germany) · 2025Article
- Diagnosing sarcopenia in pediatrics is not "vexatious" but appropriate.Pediatric nephrology (Berlin, Germany) · 2025Article
- The vexatious diagnosis of "sarcopenia" in children.Pediatric nephrology (Berlin, Germany) · 2025Article
- Pathogenesis of Sarcopenia in Chronic Kidney Disease-The Role of Inflammation, Metabolic Dysregulation, Gut Dysbiosis, and microRNA.International journal of molecular sciences · 2024Review
- Bioimpedance analysis in children on peritoneal dialysis: to fill or not to fill?Pediatric nephrology (Berlin, Germany) · 2024Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric patients with chronic kidney disease (CKD) frequently present an inadequate nutritional profile and musculoskeletal impairments. We investigated sarcopenia and its related traits in children and adolescents with CKD.
methodsA cross-sectional study that enrolled pediatric patients with CKD (≥ 4 and < 18 years old). Physical function was assessed by handgrip strength and the 60-s sit-to-stand (STS-60) tests. Body composition measurement was performed by bioelectrical impedance analysis and anthropometry through mid-upper arm circumference (MUAC). Normative reference values from healthy pediatrics were used for identifying poor physical function and low MUAC. Probable sarcopenia was considered as low handgrip strength, whereas sarcopenia was defined by adding low MUAC.
resultsTwenty-two pediatric patients with CKD (11 ± 4 years and 59% boys) were evaluated; eight on peritoneal dialysis (36%), six on hemodialysis (27%), and eight non-dialysis (36%). Regarding sarcopenia traits, we observed low physical function by handgrip strength and STS-60 in 59% and 100% of the patients, respectively, while low MUAC in 77%. Probable sarcopenia was found in 9% and sarcopenia in 50%, but prevalence did not differ among stages. Handgrip strength was strongly associated with MUAC (r = 0.90; p < 0.001); on the other hand, the STS-60 was not significantly associated with any of the body composition variables.
conclusionAmong pediatric patients with CKD, the prevalence of sarcopenia and its related traits was high. Nephrology professionals should consider the assessment of sarcopenia in this population, while more evidence is needed to determine its prognostic value. A higher resolution version of the Graphical abstract is available as Supplementary information.
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