Evidence map›Paper›PMID 37566113›Full record

ArticlePflugers Archiv : European journal of physiology2023

The context-dependent role of the Na

Thorsten Loeck, Micol Rugi, Luca Matteo Todesca, Paulina Kalinowska, Benjamin Soret, Ilka Neumann, Sandra Schimmelpfennig, Karolina Najder, Zoltán Pethő, Valerio Farfariello and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. KPflugers Archiv : European journal of physiology · 2025
    Article
  3. Membrane potential dynamics of C5a-stimulated neutrophil granulocytes.Pflugers Archiv : European journal of physiology · 2024
    Article
  4. pH-regulated single cell migration.Pflugers Archiv : European journal of physiology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Thorsten LoeckInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Micol RugiInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Luca Matteo TodescaInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Paulina KalinowskaInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Benjamin SoretInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Ilka NeumannInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Sandra SchimmelpfennigInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Karolina NajderInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Zoltán PethőInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany.
Valerio FarfarielloUniversité de Lille, Inserm, U1003 - PhyCell - Physiologie Cellulaire, F-59000, Lille, France.
Natalia PrevarskayaUniversité de Lille, Inserm, U1003 - PhyCell - Physiologie Cellulaire, F-59000, Lille, France.
Albrecht SchwabInstitute of Physiology II, University of Münster, Robert-Koch-Straße 27b, 48149, Münster, Germany. aschwab@uni-muenster.de.
University of Münster · DEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic stellate cells (PSCs) that can co-metastasize with cancer cells shape the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) by producing an excessive amount of extracellular matrix. This leads to a TME characterized by increased tissue pressure, hypoxia, and acidity. Moreover, cells within the tumor secrete growth factors. The stimuli of the TME trigger Ca

Indexed as

Pancreatic Stellate CellsSodium-Calcium ExchangerCalciumHumansHypoxiaMembrane Transport ProteinsSignal TransductionCalciumMembrane Transport ProteinsSodium-Calcium ExchangerCa2+MetastasisMigrationNa+/Ca2+-exchanger (NCX)Pancreatic stellate cells (PSCs)Tumor microenvironment (TME)

Identifiers

PMID37566113
PMCPMC10499968
OpenAlexW4385751525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.