Evidence map›Paper›PMID 37566058›Full record

ArticleCells2023

The Comet Assay in Drosophila: A Tool to Study Interactions between DNA Repair Systems in DNA Damage Responses In Vivo and Ex Vivo.

Rubén Rodríguez, Isabel Gaivão, Leticia Aguado, Marta Espina, Jorge García, Pablo Martínez-Camblor, L María Sierra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Fly · 2026
    Review
  2. Article
  3. Article
  4. Biological and Behavioral Responses ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Rubén RodríguezDepartment of Functional Biology (Genetic Area), University of Oviedo, 33006 Oviedo, Spain.
Isabel GaivãoDepartment of Genetics and Biotechnology and CECAV, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.ORCID 0000-0003-4461-7021
Leticia AguadoDepartment of Functional Biology (Genetic Area), University of Oviedo, 33006 Oviedo, Spain.
Marta EspinaDepartment of Functional Biology (Genetic Area), University of Oviedo, 33006 Oviedo, Spain.
Jorge GarcíaDepartment of Functional Biology (Genetic Area), University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0003-1566-8145
Pablo Martínez-CamblorDepartment of Biomedical Data Science, Geisel Medical School at Dartmouth, Hanover, NH 03755, USA.ORCID 0000-0001-7845-3905
L María SierraDepartment of Functional Biology (Genetic Area), University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-9046-1171
Universidad de Oviedo · ESDartmouth College · USUniversity of Trás-os-Montes and Alto Douro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The comet assay in Drosophila has been used in the last few years to study DNA damage responses (DDR) in different repair-mutant strains and to compare them to analyze DNA repair. We have used this approach to study interactions between DNA repair pathways in vivo. Additionally, we have implemented an ex vivo comet assay, in which nucleoids from treated and untreated cells were incubated ex vivo with cell-free protein extracts from individuals with distinct repair capacities. Four strains were used: wild-type OregonK (

Indexed as

DrosophilaDrosophila melanogasterAnimalsComet AssayDNA DamageDNA RepairHumansMammalsMethyl MethanesulfonateMethyl MethanesulfonatedmPolQDNA damage responseDrosophila melanogasterex vivo comet assayin vivo comet assayMMSmus308 and OK strainsmus308, mus201, mus201NER

Identifiers

PMID37566058
PMCPMC10417035
OpenAlexW4385461598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.