Evidence map›Paper›PMID 37566035›Full record

ArticleCells2023

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Aurora Gómez-Vecino, Roberto Corchado-Cobos, Adrián Blanco-Gómez, Natalia García-Sancha, Sonia Castillo-Lluva, Ana Martín-García, Marina Mendiburu-Eliçabe, Carlos Prieto, Sara Ruiz-Pinto, Guillermo Pita and 42 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

52 authors at 14 institutions in 5 countries.

Aurora Gómez-VecinoInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Roberto Corchado-CobosInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-3452-2486
Adrián Blanco-GómezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Natalia García-SanchaInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0001-7731-7020
Sonia Castillo-LluvaDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas, Universidad Complutense, 28040 Madrid, Spain.ORCID 0000-0001-5357-7178
Ana Martín-GarcíaInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.
Marina Mendiburu-EliçabeInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0003-2573-8709
Carlos PrietoServicio de Bioinformática, Nucleus, Universidad de Salamanca, 37007 Salamanca, Spain.
Sara Ruiz-PintoHuman Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Guillermo PitaHuman Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Alejandro Velasco-RuizHuman Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Carmen Patino-AlonsoInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0001-8232-6685
Purificación Galindo-VillardónInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0001-6977-7545
María Linarejos Vera-PedrosaCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, 28029 Madrid, Spain.
José JalifeCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-0080-3500
Jian-Hua MaoBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0001-9320-6021
Guillermo Macías de PlasenciaInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.
Andrés Castellanos-MartínInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0003-2864-7271
María Del Mar Sáez-FreireInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Susana Fraile-MartínServicio de Patología Molecular Comparada, Instituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca, 37007 Salamanca, Spain.
Telmo Rodrigues-TeixeiraServicio de Patología Molecular Comparada, Instituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca, 37007 Salamanca, Spain.
Carmen García-MacíasServicio de Patología Molecular Comparada, Instituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca, 37007 Salamanca, Spain.
Julie Milena Galvis-JiménezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Asunción García-SánchezInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0002-9655-4918
María Isidoro-GarcíaInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.
Manuel FuentesInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-7305-3766
María Begoña García-CenadorInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0002-8950-8542
Francisco Javier García-CriadoInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.
Juan Luis García-HernándezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-2146-5726
María Ángeles Hernández-GarcíaServicio de Hematología, Hospital Universitario de Salamanca, CIBERONC, 37007 Salamanca, Spain.
Juan Jesús Cruz-HernándezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0003-1980-2751
César Augusto Rodríguez-SánchezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Alejandro Martín García-SanchoInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0001-6330-1028
Estefanía Pérez-LópezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Antonio Pérez-MartínezDepartment of Paediatric Hemato-Oncology, Hospital Universitario La Paz, 28046 Madrid, Spain.ORCID 0000-0002-6436-9195
Federico Gutiérrez-LarrayaDepartment of Paediatric Cardiology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Antonio J CartónDepartment of Paediatric Cardiology, Hospital Universitario La Paz, 28046 Madrid, Spain.
José Ángel García-SáenzMedical Oncology Service, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0001-6880-0301
Ana Patiño-GarcíaDepartment of Pediatrics, Solid Tumor Program, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, IdisNA, 31008 Pamplona, Spain.ORCID 0000-0002-4066-8203
Miguel MartínDepartment of Medicine, Gregorio Marañón Health Research Institute (IISGM), Centro de Investigación Biomédica en Red Oncológica (CIBERONC), Universidad Complutense, 28007 Madrid, Spain.ORCID 0000-0001-9237-3231
Teresa Alonso-GordoaDepartment of Medical Oncology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Christof VulstekeDepartment of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Center for Oncological Research (CORE), Antwerp University, 2610 Antwerp, Belgium.ORCID 0000-0002-4607-5660
Lieselot CroesDepartment of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Center for Oncological Research (CORE), Antwerp University, 2610 Antwerp, Belgium.
Sigrid HatseLaboratory of Experimental Oncology (LEO), Department of Oncology, Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-6764-2628
Thomas Van BrusselVIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
Diether LambrechtsVIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
Hans WildiersDepartment of General Medical Oncology and Multidisciplinary Breast Unit, Leuven Cancer Institute, and Laboratory of Experimental Oncology (LEO), Department of Oncology, Leuven Cancer Institute and University Hospital Leuven, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-8990-7837
Hang ChangBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Marina Holgado-MadrugaInstituto de Investigación Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain.
Anna González-NeiraHuman Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.ORCID 0000-0002-5421-2020
Pedro L SánchezInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-1402-0526
Jesús Pérez LosadaInstituto de Biología Molecular y Celular del Cáncer (IBMCC-CIC), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0003-2400-624X
Universidad de Salamanca · ESSpanish National Cancer Research Centre · ESHospital Universitario La Paz · ESComplejo Hospitalario de Salamanca · ESKU Leuven · BELawrence Berkeley National Laboratory · USSpanish National Centre for Cardiovascular Research · ESUniversity of Antwerp · BEVIB-KU Leuven Center for Cancer Biology · BECentro de Investigación Biomédica en Red de Cáncer · ESHospital Universitario Ramón y Cajal · ESInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESUniversidad Complutense de Madrid · ESUniversidad de Navarra · ES

Funding

Molecular and Therapeutic Basis of Morphometric Aberrations in Brain TumorsR01CA184476 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CHANG, HANG · 2015 to 2019
$2.0M
NCI NIH HHS R01 CA184476
6 · The paper itself

Abstract

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (

Indexed as

CardiotoxicityNeoplasmsAnimalsAnthracyclinesAntibiotics, AntineoplasticFemaleGenetic MarkersMicePhenotypeAnthracyclinesAntibiotics, AntineoplasticGenetic Markersanthracyclinescardiotoxicitycomplex genetic diseaseintermediate molecular phenotypesquantitative trait loci

Identifiers

PMID37566035
PMCPMC10417374
OpenAlexW4385346855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.