ArticleCells2023
Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19.
Open access · goldAbstract read
In one paragraph
Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Clinical lipidomics in bacterial sepsis: a systematic review of serum and plasma evaluations.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Hexosylceramide Species in the Blood Decline in Both COVID-19 and Non-COVID-19 Sepsis.Biomedicines · 2026Article
- Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection.Clinical epigenetics · 2026Article
- Article
- Exploratory study of the effect of DHA supplementation on blood fatty acids and inflammatory markers in children with MIS-C.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 6 institutions in 2 countries.
Diana Mota ToroDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-1003-3848
Pedro V da Silva-NetoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0003-1209-9346
Jonatan C S de CarvalhoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0001-8776-5417
Carlos A FuzoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0003-3198-9969
Malena M PérezDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Vinícius E PimentelDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0003-3411-1545
Thais F C Fraga-SilvaDepartment of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.ORCID 0000-0002-2053-8938
Camilla N S OliveiraDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Glaucia R CarusoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.
Adriana F L VilelaDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.
Pedro Nobre-AzevedoDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.ORCID 0000-0002-2109-7484
Thiago V Defelippo-FelippeDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.ORCID 0009-0001-3354-4229
Jamille G M ArgoloDepartment of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Augusto M DegiovaniHospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil.
Fátima M OstiniHospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil.
Marley R FeitosaDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.
Rogerio S ParraDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.ORCID 0000-0002-5566-9284
Fernando C VilarHospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil.ORCID 0000-0001-8232-5375
Gilberto G GasparDepartment of Internal Medicine, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.
José J R da RochaDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.
Omar FeresDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.
Gabriel P CostaSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0003-0687-6671
Sandra R C MaruyamaDepartment of Genetics and Evolution, Center for Biological and Health Sciences, Federal University of São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil.
Elisa M S RussoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-9274-7915
Ana Paula M FernandesDepartment of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil.
Isabel K F M SantosDepartment of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.
Adriana MalheiroPostgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil.
Ruxana T SadikotDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Vânia L D BonatoDepartment of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.ORCID 0000-0003-4189-2685
Cristina R B CardosoDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-6156-3144
Marcelo Dias-BaruffiDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-2039-1884
Átila A TrapéSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0001-6487-8160
Lúcia H FaccioliDepartment of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.ORCID 0000-0002-4999-8305
Carlos A SorgiPostgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil.
ImmunoCovid Consortium Group
Universidade de Ribeirão Preto · BRUniversidade de São Paulo · BRCentro de Reprodução Humana Prof. Franco Junior · BRUniversidade Federal de São Carlos · BRUniversidade Federal do Amazonas · BRUniversity of Nebraska Medical Center · US
Funding
How HIV-related proteins increase the susceptibility to lung injury despite anti-retroviral therapyR01HL144478 · NHLBI · EMORY UNIVERSITY · PI GUIDOT, DAVID MARSHALL, SADIKOT, RUXANA T · 2019 to 2022
$1.6MTREM-1 in Lung Immune ResponseI01BX001786 · VA · VETERANS HEALTH ADMINISTRATION · PI Ruxana T Sadikot · 2013 to 2026
–BLRD VA I01 BX001786NHLBI NIH HHS R01 HL144478
Abstract
SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process and tissue damage. Sphingolipids (SLs) play pivotal roles in various cellular and tissue processes, including inflammation, metabolic disorders, and cancer. In this study, we employed high-resolution mass spectrometry to investigate SL metabolism in plasma samples obtained from control subjects (
Indexed as
COVID-19SphingomyelinsBiomarkersCeramidesHumansPrognosisSARS-CoV-2SphingolipidsBiomarkersCeramidesSphingolipidsSphingomyelinsbiomarkerCOVID-19inflammationsphingolipidssphingomyelin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.