Evidence map›Paper›PMID 37566016›Full record

ArticleCells2023

Aging-Related Accumulation of Truncated Oxidized Phospholipids Augments Infectious Lung Injury and Endothelial Dysfunction via Cluster of Differentiation 36-Dependent Mechanism.

Yunbo Ke, Pratap Karki, Yue Li, Kamoltip Promnares, Chen-Ou Zhang, Thomas L Eggerman, Alexander V Bocharov, Anna A Birukova, Konstantin G Birukov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Combatting pulmonary fibrosis withChinese herbal medicines · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yunbo KeDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Pratap KarkiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yue LiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kamoltip PromnaresDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Chen-Ou ZhangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Thomas L EggermanDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20894, USA.
Alexander V BocharovDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20894, USA.
Anna A BirukovaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Konstantin G BirukovDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0303-5394
University of Maryland, Baltimore · USNational Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Control of Lung Permeability by Oxidized PhospholipidsR01HL076259 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOV, KONSTANTIN · 2004 to 2023
$6.8M
Control of septic inflammation and lung microvascular endothelial barrier by cell junction signaling nexusR01HL152761 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOVA, ANNA · 2021 to 2024
$2.2M
Mechanisms of microvascular endothelial cell injury caused by extracellular histonesR01HL155051 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOVA, ANNA · 2021 to 2024
$1.8M
Modulation of inflammation in aging lungR01HL146829 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOV, KONSTANTIN · 2020 to 2023
$1.5M
NHLBI NIH HHS R01 HL076259NHLBI NIH HHS R01 HL146829NHLBI NIH HHS R01 HL152761NHLBI NIH HHS R01 HL155051
6 · The paper itself

Abstract

Truncated phospholipid oxidation products (Tr-OxPL) increase in blood circulation with aging; however, their role in the severity of vascular dysfunction and bacterial lung injury in aging groups remains poorly understood. We investigated the effects of six Tr-OxPL species: KOdiA-PC, POVPC, PONPC, PGPC, Paz-PC, and Lyso-PC on endothelial dysfunction and lung inflammation caused by heat-killed

Indexed as

Lung InjuryPneumoniaAgingAnimalsEndothelial CellsMicePhospholipidsPhospholipidsagingbacterial pathogensCD36inflammationL37pAlung injuryoxidized phospholipidsshort amphipathic helical peptides

Identifiers

PMID37566016
PMCPMC10416939
OpenAlexW4385360692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.