Evidence map›Paper›PMID 37566006›Full record

ArticleCells2023

Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the

Marika Premoli, William Fyke, Luigi Bellocchio, Valerie Lemaire, Marie Wolley-Roberts, Bruno Bontempi, Susanna Pietropaolo

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Marika PremoliCNRS, EPHE, INCIA, UMR 5287, Univ. Bordeaux, 33000 Bordeaux, France.ORCID 0000-0002-2948-7524
William FykeCNRS, EPHE, INCIA, UMR 5287, Univ. Bordeaux, 33000 Bordeaux, France.ORCID 0000-0001-8389-9899
Luigi BellocchioINSERM, U1215 NeuroCentre Magendie, Group Endocannabinoids and Neuroadaptation, University of Bordeaux, 33077 Bordeaux, France.
Valerie LemaireCNRS, EPHE, INCIA, UMR 5287, Univ. Bordeaux, 33000 Bordeaux, France.
Marie Wolley-RobertsJazz Pharmaceuticals, Inc., Cambridge OX4 2RW, UK.
Bruno BontempiCNRS, EPHE, INCIA, UMR 5287, Univ. Bordeaux, 33000 Bordeaux, France.
Susanna PietropaoloCNRS, EPHE, INCIA, UMR 5287, Univ. Bordeaux, 33000 Bordeaux, France.ORCID 0000-0002-8993-1922
Centre National de la Recherche Scientifique · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytocannabinoids, including the non-addictive cannabis component cannabidivarin (CBDV), have been reported to hold therapeutic potential in several neurodevelopmental disorders (NDDs). Nonetheless, the therapeutic value of phytocannabinoids for treating Fragile X syndrome (FXS), a major NDD, remains unexplored. Here, we characterized the neurobehavioral effects of CBDV at doses of 20 or 100 mg/kg in the

Indexed as

Fragile X SyndromeAnimalsAnxietyCannabinoidsFragile X Messenger Ribonucleoprotein 1MiceMice, KnockoutcannabidivarinCannabinoidsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Fmr1interleukinsmouse behaviorneurodevelopmental disordersneurotrophinsphytocannabinoids

Identifiers

PMID37566006
PMCPMC10416983
OpenAlexW4385278826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.