Evidence map›Paper›PMID 37565994›Full record

ArticleGlobal spine journal2025

The Effect of Changes in Segmental Lordosis on Global Lumbar and Adjacent Segment Lordosis After L5-S1 Anterior Lumbar Interbody Fusion.

Austin Q Nguyen, Jackson P Harvey, Vincent P Federico, Michael T Nolte, Krishn Khanna, Sapan D Gandhi, Evan D Sheha, Matthew W Colman, Frank M Phillips

Open access · goldAbstract read
In one paragraph

Article in Global spine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The impact of preoperative lordosis distribution index on postoperative sagittal alignment and outcomes after lumbar fusion surgery for degenerative spine disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Austin Q NguyenDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0001-6451-4412
Jackson P HarveyDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Vincent P FedericoDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0003-3749-9282
Michael T NolteDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0001-9293-270X
Krishn KhannaOrthopaedics Northeast P.C., Andover, MA, USA.
Sapan D GandhiDepartment of Orthopedic Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-9250-1421
Evan D ShehaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0003-4339-6079
Matthew W ColmanDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Frank M PhillipsDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Rush University Medical Center · USBeth Israel Deaconess Medical Center · USHospital for Special Surgery · USNortheast Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designRetrospective Cohort Study.

objectiveRestoration of lordosis in lumbar fusion reduces low back pain, decreases adjacent segment degeneration, and improves postoperative outcomes. However, the potential effects of changes in segmental lordosis on adjacent-level and global lordosis remain less understood. This study aims to examine the relationships between segmental (SL), adjacent-level, and global lumbar lordosis following L5-S1 Anterior Lumbar Interbody Fusion (ALIF).

methods80 consecutive patients who underwent single-level L5-S1 ALIF were divided into 3 groups based on the degree of change (∆) in index-level segmental lordosis: <5° (n = 23), 5°-10° (n = 29), >10° (n = 28). Radiographic parameters measured included global lumbar, segmental, and adjacent level lordosis, sacral slope, pelvic tilt, pelvic incidence, and PI-LL mismatch.

resultsPatients with ∆SL 5°-10° or ∆SL >10° both showed significant increases in global lumbar lordosis from preoperative to final follow-up. However, patients with ∆SL >10° showed statistically significant losses in adjacent level lordosis at both immediate postoperative and final follow-up compared to preoperative. When comparing patients with ∆SL >10° to those with ∆SL 5-10°, there were no significant differences in global lumbar lordosis at final follow-up, due to significantly greater losses of adjacent level lordosis in these patients.

conclusionThe degree of compensatory loss of lordosis at the adjacent level L4-L5 correlated with the extent of segmental lordosis creation at the index L5-S1 level. This may suggest that the L4 to S1 segment acts as a "harmonious unit," able to accommodate only a certain amount of lordosis and further increases in segmental lordosis may be mitigated by loss of adjacent-level lordosis.

Indexed as

adjacent segment lordosisanterior lumbar interbody fusionglobal lordosisL5-S1minimally invasivesagittal alignmentsegmental lordosisspine

Identifiers

PMID37565994
PMCPMC11696948
OpenAlexW4385751467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.