Evidence map›Paper›PMID 37565671›Full record

ReviewThe Journal of international medical research2023

Autoimmune myasthenia gravis and COVID-19. A case report-based review.

Cristina Georgiana Croitoru, Dan Iulian Cuciureanu, Diana Nicoleta Hodorog, Cristina Grosu, Petru Cianga

Abstract readCase ReportsReview
In one paragraph

Review in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Double-seropositive Myasthenia Gravis Following COVID-19.Internal medicine (Tokyo, Japan) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cristina Georgiana CroitoruDepartment of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.ORCID 0000-0003-2530-0758
Dan Iulian CuciureanuNeurology Clinic, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, Iași, Romania.
Diana Nicoleta HodorogNeurology Clinic, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, Iași, Romania.
Cristina GrosuDepartment Medical III, Department of Neurology," Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.
Petru CiangaDepartment of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A potential relationship between COVID-19 infection and new onset myasthenia gravis (MG) has been suggested by the coexistence of these two diseases in a number of reports. This study aimed to assess their relationship by reviewing case studies of COVID-19 followed by new onset MG published between 01 December 2019 and 30 June 2023 identified by a search of PubMed/Medline database. In addition, we reviewed evidence in favour and against a potential cause and effect association, and described possible mechanisms that would underpin such a relationship. We identified 14 publications that reported 18 cases. Analysis showed the following features: age 19-83 years; 10 men/8 women; median time interval between COVID-19 and MG (17, 5-56 days); autoimmune comorbidities (4); generalised MG (14); ocular MG (4); thymoma (3); antiacetylcholine receptor antibody (16); antimuscle-specific kinase antibodies (2). All patients improved following treatment. Proof of direct causality between the two conditions can only be established in time by confirming epidemiological increase in the incidence of MG or elucidating pathogenic mechanisms to substantiate a possible cause-effect association, or both.

Indexed as

COVID-19Myasthenia GravisThymomaThymus NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedReceptors, CholinergicYoung AdultReceptors, CholinergicAutoimmuneCOVID-19myasthenia gravis

Identifiers

PMID37565671
PMCPMC10422912

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.