ArticleThe EMBO journal2023
WRKY transcription factors and OBERON histone-binding proteins form complexes to balance plant growth and stress tolerance.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 45 citations in OpenAlex.
- Article
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- How WRKY transcription factors fine-tune specificity in plant stress responses: from W-box to regulatory code.Molecular biology reports · 2026Review
- NbVQ1 physically turns off the NbWRKY45-NbCAT2 module to promote reactive oxygen species burst and disease resistance in plants under high-potassium regime.Plant physiology · 2026Article
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2026Article
- JUND-driven stress-responsive astrocytes promote neuronal apoptosis via enhanced gap junction signaling in autism spectrum disorder.Molecular autism · 2026Article
- Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration.Molecular plant · 2026Article
- Serial Spatial Transcriptomes Reveal Regulatory Transitions in Maize Leaf Development.Plant biotechnology journal · 2026Article
- Genome-wide identification and functional analysis of the WRKY transcription factor family in Reynoutria japonica reveals its role in balancing growth and abiotic stress tolerance.BMC plant biology · 2026Article
- SlNAC63-SlbHLH71 module enhances tomato saline-alkali tolerance via regulating JA biosynthesis and ROS scavenging.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Whole genome resequencing analysis of tobacco K326 and its cold sensitive mutant M18.Frontiers in plant science · 2026Article
- Genome-wide characterization of WRKYs and identification of SpWRKY40 and SpWRKY51 as transcription activators in Sesuvium portulacastrum.Functional & integrative genomics · 2025Article
- Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- WRKY transcription factor RrWRKY56 negatively regulates salt and drought stress tolerance by suppressing RrUSP expression in Rosa rugosa.BMC plant biology · 2025Article
- Nutrient-driven TOR signalling controls a chromatin-associated complex for orchestrating plant growth and stress tolerance.Nature plants · 2025Article
- WRKYs as regulatory hubs of secondary metabolic networks: Diverse inducers and distinct responses.Plant communications · 2025Review
- Transcription Factor LjWRKY50 Affects Jasmonate-Regulated Floral Bud Duration inPlants (Basel, Switzerland) · 2025Article
- Time-Series Metabolome and Transcriptome Analyses Reveal the Genetic Basis of Vanillin Biosynthesis in Vanilla.Plants (Basel, Switzerland) · 2025Article
- Transcriptome analysis and genome-wide identification of WRKY gene family in Leonurus japonicus under drought stress.BMC plant biology · 2025Article
- Genome-wide association study (GWAS) provides insights into the genomic basis of reproduction-related traits in Chouardia litardierei (Asparagaceae).BMC plant biology · 2025Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
WRKY transcription factors in plants are known to be able to mediate either transcriptional activation or repression, but the mechanism regulating their transcriptional activity is largely unclear. We found that group IId WRKY transcription factors interact with OBERON (OBE) proteins, forming redundant WRKY-OBE complexes in Arabidopsis thaliana. The coiled-coil domain of WRKY transcription factors binds to OBE proteins and is responsible for target gene selection and transcriptional repression. The PHD finger of OBE proteins binds to both histones and WRKY transcription factors. WRKY-OBE complexes repress the transcription of numerous stress-responsive genes and are required for maintaining normal plant growth. Several WRKY and OBE mutants show reduced plant size and increased drought tolerance, accompanied by increased expression of stress-responsive genes. Moreover, expression levels of most of these WRKY and OBE genes are reduced in response to drought stress, revealing a previously uncharacterized regulatory mechanism of the drought stress response. These results suggest that WRKY-OBE complexes repress transcription of stress-responsive genes, and thereby balance plant growth and stress tolerance.
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