Observational studyEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023
Clinical outcomes of TAVI with the Myval balloon-expandable valve for non-calcified aortic regurgitation.
Observational study in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07751965 (Prospective, Multicenter, Single-arm, Open-label Study Evaluating the Safety and Effectiveness of the Myval Transcatheter Heart Valve), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Multicenter, Single-arm, Open-label Study Evaluating the Safety and Effectiveness of the Myval Transcatheter Heart Valve (THV) System in High-risk Patients With Severe Symptomatic Non- or Mildly Calcified Aortic Regurgitation.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dedicated Versus Conventional Devices in Patients With Pure Native Aortic Regurgitation: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Comparative outcomes of on-label and off-label transcatheter aortic valve replacement for aortic regurgitation: a systematic review and meta-analysis.Open heart · 2025Pooled it
- Self-expanding intraannular transcatheter heart valve in tapered LVOT morphology - impact on deployment precision and periprocedural aortic prosthesis migration.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Myval Octacor and Octapro TInternational journal of cardiology. Heart & vasculature · 2026Article
- Transcatheter Aortic Valve Replacement for Treating Native Aortic Regurgitation: Ready for Prime Time?Structural heart : the journal of the Heart Team · 2025Review
- Redo Transcatheter Aortic Valve Replacement for Migration of Myval Transcatheter Heart Valve in Pure Aortic Regurgitation.JACC. Case reports · 2025Article
- Transcatheter aortic valve replacement for older patients with isolated aortic regurgitation.Journal of geriatric cardiology : JGC · 2025Article
- A systematic review and meta-analysis of the hemodynamics and outcomes of the Myval balloon-expandable valve in patients with severe aortic stenosis and with aortic regurgitation.International journal of cardiology. Heart & vasculature · 2025Article
- Patient-specific Factors Influencing Choice of Transcatheter Aortic Valve Prosthesis.Interventional cardiology (London, England) · 2025Review
- Transcatheter Aortic Valve Replacement for Aortic Insufficiency.Interventional cardiology (London, England) · 2025Review
- Myval Transcatheter Heart Valve: The Future of Transcatheter Valve Replacement and Significance in Current Timeline.Journal of clinical medicine · 2024Review
- Aortic regurgitation: from mechanisms to management.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Review
- Quantitative Aortography Analysis of JenaValve's Trilogy Transcatheter Aortic Valve Implantation System in Patients With Aortic Regurgitation or Stenosis.Structural heart : the journal of the Heart Team · 2024Article
- Transcatheter aortic valve implantation: the shape matters.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Transcatheter aortic valve replacement for noncalcified aortic regurgitation. Where are we now?REC, interventional cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter aortic valve replacement (TAVR) in non-calcified aortic regurgitation (NCAR) is an off-label procedure. The balloon-expandable Myval includes extra-large sizes (30.5 mm and 32 mm) of interest in this setting.
aimsWe aimed to evaluate the safety and feasibility of Myval in NCAR.
methodsThis was an international, multicentre, observational study that enrolled all consecutive patients with symptomatic severe NCAR undergoing TAVR with the Myval device. The images were centrally analysed.
resultsA total of 113 patients were recruited, 64.6% were men, the mean age was 78.4±7.5 years, and the Society of Thoracic Surgeons score was 2.7±1.7%. Aortic root dilatation was present in 59.3% of patients, 7.1% were bicuspid, and the mean annular area was 638.6±106.0 mm
conclusionsMyval is a feasible and safe option for selected non-operable patients with NCAR and demonstrated good midterm outcomes and lack of impact of oversizing on device durability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.