Evidence map›Paper›PMID 37565378›Full record

ArticleAdvanced healthcare materials2023

Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs.

Srujan Singh, Yuxiao Zhou, Ashley L Farris, Emma C Whitehead, Ethan L Nyberg, Aine N O'Sullivan, Nicholas Y Zhang, Alexandra N Rindone, Chukwuebuka C Achebe, Wojciech Zbijewski and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Srujan SinghDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Yuxiao ZhouTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Ashley L FarrisTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Emma C WhiteheadTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Ethan L NybergTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Aine N O'SullivanTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Nicholas Y ZhangTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Alexandra N RindoneTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Chukwuebuka C AchebeTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Wojciech ZbijewskiDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Will GrundyStageBio Company, Mount Jackson, VA, 22842, USA.
David GarlickStageBio Company, Mount Jackson, VA, 22842, USA.
Nicolette D JacksonInotiv, Fort Collins, CO, 80524, USA.
Dara KraitchmanDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jessica M IzziDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Joseph LopezPediatric Plastic and Reconstructive Surgery, Pediatric Head and Neck Surgery, AdventHealth for Children, Orlando, FL, 32803, USA.
Michael P GrantDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Warren L GraysonDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0001-6099-6469
Johns Hopkins University · USThe Mount · GBAdventHealth for Children · USAgricultural Research Service - Plains Area · USUniversity of Maryland, Baltimore · US

Funding

Oxygen-eluting scaffolds for cranial bone regenerationR01DE027957 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, PATHAK, ARVIND P · 2019 to 2023
$2.4M
NIDCR NIH HHS R01 DE027957NIH HHS R01DE027957
6 · The paper itself

Abstract

Porous tissue-engineered 3D-printed scaffolds are a compelling alternative to autografts for the treatment of large periorbital bone defects. Matching the defect-specific geometry has long been considered an optimal strategy to restore pre-injury anatomy. However, studies in large animal models have revealed that biomaterial-induced bone formation largely occurs around the scaffold periphery. Such ectopic bone formation in the periorbital region can affect vision and cause disfigurement. To enhance anatomic reconstruction, geometric mismatches are introduced in the scaffolds used to treat full thickness zygomatic defects created bilaterally in adult Yucatan minipigs. 3D-printed, anatomically-mirrored scaffolds are used in combination with autologous stromal vascular fraction of cells (SVF) for treatment. An advanced image-registration workflow is developed to quantify the post-surgical geometric mismatch and correlate it with the spatial pattern of the regenerating bone. Osteoconductive bone growth on the dorsal and ventral aspect of the defect enhances scaffold integration with the native bone while medio-lateral bone growth leads to failure of the scaffolds to integrate. A strong positive correlation is found between geometric mismatch and orthotopic bone deposition at the defect site. The data suggest that strategic mismatch >20% could improve bone scaffold design to promote enhanced regeneration, osseointegration, and long-term scaffold survivability.

Indexed as

Printing, Three-DimensionalTissue ScaffoldsAnimalsBiocompatible MaterialsBone RegenerationOsteogenesisSwineSwine, MiniatureBiocompatible Materials3D-printingbone regenerationgeometric mismatchimage registrationmidfacialscaffoldsYucatan pigs

Identifiers

PMID37565378
PMCPMC10840722
OpenAlexW4385724307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.