ReviewFrontiers in pediatrics2023
Neonatal respiratory support strategies-short and long-term respiratory outcomes.
Review in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Acceptability of immediate CPAP for preterm infants in the delivery room to mothers, caregivers and healthcare workers in a low-resource setting: a qualitative study.BMC pediatrics · 2025Trial
- Association between 24-hour urine output during early non-invasive ventilation and short-term adverse outcomes in late preterm infants: a retrospective cohort study.Translational pediatrics · 2026Article
- Serial lung ultrasound scoring for predicting invasive mechanical ventilation in preterm neonates: a prospective diagnostic accuracy study.European journal of pediatrics · 2026Article
- Factors Associated with Severe Respiratory Support Requirement in Neonates with Gram-Negative Infections: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Development and validation of the Prognostic Respiratory Intensity Scoring Metric (PRISM).BMC pediatrics · 2026Article
- Neurally Adjusted Ventilatory Assist Compared with Volume-Targeted and Pressure-Controlled Modes in Preterm Infants with Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- Early Outcomes and Associated Factors in Neonates with Extremely Low Birth Weight Admitted to the Neonatal Intensive Care Unit at Selected Referral Hospitals in Kigali.Rwanda journal of medicine and health sciences · 2026Article
- Development and internal validation of a clinical nomogram for predicting bronchopulmonary dysplasia in preterm infants.Experimental and therapeutic medicine · 2026Article
- A survey of parental experiences and perceptions of NAVA in neonatal intensive care.European journal of pediatrics · 2026Article
- Application of a combined predictive model based on lung ultrasound score trajectory changes in deciding mechanical ventilator weaning for neonatal respiratory distress syndrome: a retrospective study.Frontiers in medicine · 2026Article
- Non-invasive respiratory support attenuates lung damage in a murine model of bronchopulmonary dysplasia.Frontiers in pediatrics · 2026Article
- Integrated follow-up of former extremely preterm infants: how to do it?European journal of pediatrics · 2025Review
- Assessment of equipment and human resources in a national survey of neonatal resuscitation in Iran.Scientific reports · 2025Article
- Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Respiratory Support Strategies for Surgical Neonates: A Review.Children (Basel, Switzerland) · 2025Review
- Elimination ofAntibiotics (Basel, Switzerland) · 2025Article
- Molecular Approach of Oxidative Stress and Bronchopulmonary Dysplasia: Relationship of GSTM1 and GSTT1 Genes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Neonatal Training across Union of European Medical Specialists Member Countries: A Survey from the Next Generation of Neonatologists.Neonatology · 2025Article
- Interpretable machine learning model for comparing and validating three diagnostic criteria for bronchopulmonary dysplasia in predicting value of respiratory prognosis of preterm infants: a retrospective cohort study.Frontiers in pediatrics · 2025Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical ventilation (MV), although life-saving, is associated with chronic respiratory morbidity in both preterm and term born infants. New ventilation modes have been developed with the aim of minimising lung injury. These include invasive and non-invasive respiratory support strategies, techniques for less invasive surfactant administration (LISA) and closed-loop automated oxygen control (CLAC) systems. Increasingly, newborn infants with signs of respiratory distress are stabilised on continuous positive airway pressure (CPAP) and receive LISA. Early CPAP when compared to mechanical ventilation reduced the incidence of BPD and respiratory morbidity at 18 to 22 months corrected age. Nasal intermittent positive pressure ventilation reduced treatment failure rates compared to CPAP, but not bronchopulmonary dysplasia (BPD). LISA compared with intubation and surfactant delivery reduced BPD, but there is no evidence from randomised trials regarding long-term respiratory and neurodevelopmental outcomes. Synchronisation of positive pressure inflations with the infant's respiratory efforts used with volume targeting should be applied for infants requiring intubation as this strategy reduces BPD. A large RCT with long term follow up data demonstrated that prophylactic high frequency oscillatory ventilation (HFOV) improved respiratory and functional outcomes at school age, but those effects were not maintained after puberty. CLAC systems appear promising, but their effect on long term clinical outcomes has not yet been explored in randomised trials. Further studies are required to determine the role of newer ventilation modes such as neurally adjusted ventilator assist (NAVA). All such respiratory support strategies should be tested in randomised controlled trials powered to assess long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.