Evidence map›Paper›PMID 37564944›Full record

ArticleAnnals of surgical treatment and research2023

Atypical parathyroid tumor: clinical and parathyroid hormone response to surgical treatment.

Antonio Giulio Napolitano, Massimo Monacelli, Valeria Liparulo, Eleonora Coviello, Domenico Pourmolkara, Stefano Avenia, Andrea Polistena

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical treatment and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Antonio Giulio NapolitanoThoracic Surgery Unit, Department of Surgical Sciences, Santa Maria della Misericordia University Hospital, University of Perugia Medical School, Perugia, Italy.ORCID https://orcid.org/0000-0002-4058-5539
Massimo MonacelliThoracic Surgery Unit, Department of Surgical Sciences, Santa Maria della Misericordia University Hospital, University of Perugia Medical School, Perugia, Italy.ORCID https://orcid.org/0009-0004-3955-7735
Valeria LiparuloThoracic Surgery Unit, Department of Surgical Sciences, Santa Maria della Misericordia University Hospital, University of Perugia Medical School, Perugia, Italy.ORCID https://orcid.org/0009-0007-3837-3899
Eleonora CovielloThoracic Surgery Unit, Department of Surgical Sciences, Santa Maria della Misericordia University Hospital, University of Perugia Medical School, Perugia, Italy.ORCID https://orcid.org/0009-0002-1963-8592
Domenico PourmolkaraThoracic Surgery Unit, Department of Surgical Sciences, Santa Maria della Misericordia University Hospital, University of Perugia Medical School, Perugia, Italy.ORCID https://orcid.org/0000-0002-4553-3973
Stefano AveniaEndocrine Surgery Unit, Department of Surgical Sciences, Santa Maria University Hospital, University of Perugia Medical School, Terni, Italy.ORCID https://orcid.org/0000-0002-5818-6405
Andrea PolistenaDepartment of Surgery, Policlinico Umberto I, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0000-0002-1319-1147
University of Perugia · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Primary hyperparathyroidism (PHPT) is caused by typical adenoma (TA), multiglandular disease (MD), or parathyroid carcinoma (PC), and in a smaller percentage of cases by atypical parathyroid tumor (APT). The objective of this study is the retrospective analysis of clinical features and parathyroid hormone (PTH)/calcium response to surgery in patients who underwent parathyroidectomy for symptomatic PHPT with histological evidence of APT. Methods: We retrospectively reviewed our institutional experience in the management of PHPT from January 2016 to December 2021 focusing on those patients presenting APTs. We analyzed the clinical features of this disease and PTH/calcium response to surgical treatment in APTs compared to the other pathological conditions causing PHPT. Results: In a cohort of 125 patients with PHPT we found 112 TAs (89.6%), 6 APTs (4.8%), 6 PCs (4.8%), and only 1 MD (0.8%). APTs in comparison to other parathyroid diseases showed peculiar features such as adhesion to the surrounding structures and a frequent intrathyroidal location, which may justify thyroid loboistmectomy adopted in most of the observed cases. APTs showed significantly higher preoperative PTH values compared to TA + MD and were relevant to PC. Conclusion: Due to its rarity, there is a lack of specific indications in the management of APTs. Biochemical features observed in APT and PC can be related to similar biological behavior. However, some specific features observed preoperatively in some cases of PHPT might suggest presence of an APT, which could be helpful mostly in surgical and postoperative management. Further studies are required to confirm the results of the present preliminary report.

Indexed as

Atypical parathyroid tumorLoboistmectomyParathyroidectomyParathyroid hormonePrimary hyperparathyroidism

Identifiers

PMID37564944
PMCPMC10409632
OpenAlexW4385640677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.