Evidence map›Paper›PMID 37563851›Full record

ArticleActa obstetricia et gynecologica Scandinavica2023

Fetal electrocardiography and artificial intelligence for prenatal detection of congenital heart disease.

Ivar R de Vries, Judith O E H van Laar, Marieke B van der Hout-van der Jagt, Sally-Ann B Clur, Rik Vullings

Abstract read
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
  8. Review
  9. Diagnosis and Management of Fetal Arrhythmias in the Current Era.Journal of cardiovascular development and disease · 2024
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivar R de VriesDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0000-0002-0579-4220
Judith O E H van LaarDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0000-0001-5350-3267
Marieke B van der Hout-van der JagtDepartment of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.ORCID 0000-0002-5805-5333
Sally-Ann B ClurDepartment of Pediatric Cardiology, Emma Children's Hospital, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.ORCID 0000-0001-5276-1475
Rik VullingsDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID 0000-0002-2392-6098

Funding

ZonMw 10070022010001
6 · The paper itself

Abstract

introductionThis study aims to investigate non-invasive electrocardiography as a method for the detection of congenital heart disease (CHD) with the help of artificial intelligence. MATERIAL AND

methodsAn artificial neural network was trained for the identification of CHD using non-invasively obtained fetal electrocardiograms. With the help of a Bayesian updating rule, multiple electrocardiographs were used to increase the algorithm's performance.

resultsUsing 122 measurements containing 65 healthy and 57 CHD cases, the accuracy, sensitivity, and specificity were found to be 71%, 63%, and 77%, respectively. The sensitivity was however 75% and 69% for CHD cases requiring an intervention in the neonatal period and first year of life, respectively. Furthermore, a positive effect of measurement length on the detection performance was observed, reaching optimal performance when using 14 electrocardiography segments (37.5 min) or more. A small negative trend between gestational age and accuracy was found.

conclusionsThe proposed method combining recent advances in obtaining non-invasive fetal electrocardiography with artificial intelligence for the automatic detection of CHD achieved a detection rate of 63% for all CHD and 75% for critical CHD. This feasibility study shows that detection rates of CHD might improve by using electrocardiography-based screening complementary to the standard ultrasound-based screening. More research is required to improve performance and determine the benefits to clinical practice.

Indexed as

Artificial IntelligenceHeart Defects, CongenitalBayes TheoremElectrocardiographyFemaleFetal HeartHumansInfant, NewbornPregnancyUltrasonography, Prenatalartificial intelligencecongenital heart diseasefetal electrocardiographyfetal heartprenatal diagnosis

Identifiers

PMID37563851
PMCPMC10577634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.