ArticleJournal of ovarian research2023
Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome.
Article in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Genetic evidence for the causal association between type 1 diabetes and the risk of polycystic ovary syndrome.Human genomics · 2023Pooled it
- Polycystic Ovary Syndrome Revisited: Novel Insights and Updates.International journal of medical sciences · 2026Review
- Hyperprolactinemia in children and adolescents: clinical characteristics and etiological spectrum.European journal of pediatrics · 2025Article
- Metabolomics of follicular fluid reveals the impact of heat stress on oocyte pick-up and in vitro embryo production efficiency in dairy cows.Journal of animal science · 2025Article
- The relationship between polycystic ovary syndrome and gynecological cancers: neurotransmitter metabolism changes and immune regulation.Frontiers in immunology · 2025Review
- What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review.Reviews in endocrine & metabolic disorders · 2024Review
- The vaginal metabolomics profile with features of polycystic ovary syndrome: a pilot investigation in China.PeerJ · 2024Article
- Perspective Exploring Novel Associations of IL-18 Levels as a Mediator of the Causal Links between Major Depression and Reproductive Health.Depression and anxiety · 2024Article
- Prolactin in Polycystic Ovary Syndrome: Metabolic Effects and Therapeutic Prospects.Life (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
Abstract
Polycystic ovarian syndrome (PCOS) is a disorder with a foundation of neuroendocrine dysfunction, characterized by increased gonadotropin-releasing hormone (GnRH) pulsatility, which is antagonized by dopamine. The dopamine receptor 2 (DRD2), encoded by the DRD2 gene, has been shown to mediate dopamine's inhibition of GnRH neuron excitability through pre- and post-synaptic interactions in murine models. Further, DRD2 is known to mediate prolactin (PRL) inhibition by dopamine, and high blood level of PRL have been found in more than one third of women with PCOS. We recently identified PRL as a gene contributing to PCOS risk and reported DRD2 conferring risk for type 2 diabetes and depression, which can both coexist with PCOS. Given DRD2 mediating dopamine's action on neuroendocrine profiles and association with metabolic-mental states related to PCOS, polymorphisms in DRD2 may predispose to development of PCOS. Therefore, we aimed to investigate whether DRD2 variants are in linkage to and/or linkage disequilibrium (i.e., linkage and association) with PCOS in Italian families. In 212 Italian families, we tested 22 variants within the DRD2 gene for linkage and linkage disequilibrium with PCOS. We identified five novel variants significantly linked to the risk of PCOS. This is the first study to identify DRD2 as a risk gene in PCOS, however, functional studies are needed to confirm these results.
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