Evidence map›Paper›PMID 37563533›Full record

ArticleBulletin of experimental biology and medicine2023

The Role of Intracellular Signaling Molecules in Macrophage Activation by Peat Humic Acids.

E S Trofimova, M V Zykova, A A Ligacheva, M G Danilets, E Yu Sherstoboev, N S Selivanova, M V Belousov, L A Logvinova, V V Zhdanov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

E S TrofimovaE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. trofimova_es@pharmso.ru.
M V ZykovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
A A LigachevaE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M G DaniletsE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E Yu SherstoboevE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
N S SelivanovaE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M V BelousovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
L A LogvinovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
V V ZhdanovE. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Siberian State Medical University · RUTomsk National Research Medical Center · RURussian Academy of Sciences · RUResearch Institute of Pharmacology and Regenerative Medicine named ED Goldberg · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humic acids isolated by sodium pyrophosphate extraction from various types of peat activate macrophages in the classical proinflammatory pathway and stimulate nitric oxide production by these cells. This effect is mediated by activation of intracellular signaling pathways involving MAPK p38, PI3K, MEK 1/2 kinase, cAMP, and NF-κB via TLR-2 and TLR-4 receptors.

Indexed as

Humic SubstancesSoilLipopolysaccharidesMacrophage ActivationNF-kappa BNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesSignal TransductionHumic SubstancesLipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesSoilhumic acidsmacrophagesnitric oxidesignaling molecules

Identifiers

PMID37563533
OpenAlexW4385719269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.