Observational studyInternal and emergency medicine2023
Albumin as a prognostic marker of 30-day mortality in septic patients admitted to the emergency department.
Observational study in Internal and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Dynamic Assessment of the C-Reactive Protein-to-Albumin Ratio Improves Early Prediction of Severe Acute Pancreatitis: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Prognostic Value of the Albumin-to-Prealbumin Ratio in Elderly Patients with Sepsis.Journal of clinical medicine · 2026Article
- The prognostic value of red cell distribution width-to-albumin ratio for 28-day mortality in sepsis patients: a multicenter analysis based on the eICU Collaborative Research Database.Frontiers in medicine · 2026Article
- Association between red blood cell distribution width to albumin ratio and pneumonia risk in acute ischemic stroke: evidence from two independent cohorts.Frontiers in nutrition · 2026Article
- Article
- Early Prediction of Septic Shock in Severe COVID-19 Patients: Development and Validation of a Nomogram Model.Infection and drug resistance · 2026Article
- Prognostic value of the advanced lung cancer inflammation index for 28 day mortality in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Article
- Precision Profiling of Disease Progression in Murine Models of Sepsis and Septic Shock.International journal of molecular sciences · 2025Article
- Serum Albumin is Linearly and Negatively Associated With the Risk of All-cause and Cardiovascular Death in Coronary Heart Disease Patients.Reviews in cardiovascular medicine · 2025Article
- Nonlinear relationship between fibrinogen-to-albumin ratio and mortality in critically ill patients with sepsis: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Article
- Risk prediction of all-cause mortality in hospitalized patients with severe acute pancreatitis by serum urea nitrogen/albumin ratio.PloS one · 2025Article
- Prognostic value of laboratory markers and clinical scores for mortality in intensive care unit patients with sepsis.PloS one · 2025Article
- Establishment and validation of a 28-day mortality prediction model based on the lactate dehydrogenase/albumin ratio in patients with severe pneumonia.Frontiers in medicine · 2025Article
- Correlation between lactate/albumin ratio and 28-day mortality in sepsis-associated acute kidney injury patients.Frontiers in medicine · 2025Article
- Article
- Association of nadir serum albumin during hospitalization with mortality in ICU patients with spontaneous intracerebral hemorrhage.Frontiers in neurologyArticle
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessing the evolutive risk of septic patients in the emergency department (ED) is very complex. Predictive tools are available, but at an early stage, none of them can detect the tissue microvascular alterations underlying the septic process. Hypoalbuminemia is present in critically ill patients in the ICU, and some early indications also suggest its early role in septic patients.
aimTo investigate the role of serum albumin concentration in predicting 30-day mortality among patients with sepsis at their first evaluation in the ED.
methodsProspective observational study enrolling all patients with sepsis evaluated consecutively at the ED of the Merano Hospital from January to December 2021. The serum albumin concentration on admission was measured immediately upon patient arrival. A multivariate logistic regression model adjusted for possible confounders assessed the association between albumin levels at admission and 30-day mortality. Kaplan-Meier survival analysis was used to evaluate 30-day mortality between groups, and receiver operating characteristic (ROC) curve analysis was used to assess the discriminatory ability of albumin in predicting mortality.
results459 patients with community-acquired sepsis were included. 17% (78/459) of patients died within 30 days. In surviving patients, the mean albumin level was 3.6 g/dL (SD 0.5), while among non-survivors it was 3.1 g/dL (SD 0.4), p < 0.001. The area under the ROC was 0.754 (95% CI 0.701-0.807). Multivariate analysis found that albumin was an independent risk factor for 30-day mortality, with an adjusted risk ratio of 2.991 (95% CI 1.619-5.525, p < 0.001) for each 1 g/dL decrease in albumin.
conclusionsSerum albumin concentration measured during initial ED assessment can be a useful prognostic marker of 30-day mortality in septic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.