ArticleNature immunology2023
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 499 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
499citing papers in PubMed, 5 pooled it
108.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
499 citing papers in PubMed, 5 syntheses or guidelines pooled it, 694 citations in OpenAlex.
- Circulating Inflammatory Proteins and Fuchs Endothelial Corneal Dystrophy: A Mendelian Randomization and Bioinformatics-Based Investigation.Translational vision science & technology · 2026Pooled it
- Circulating inflammatory proteins associated with risks of schizophrenia, bipolar disorder, and major depressive disorder: a mendelian randomization study.Translational psychiatry · 2025Pooled it
- Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization.Renal failure · 2025Pooled it
- Genome-wide association study and polygenic risk prediction of hypothyroidism.Nature genetics · 2025Pooled it
- Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Pooled it
- A Mendelian randomization study reveals TNF-β as a potential protective factor against sarcopenia.Medicine · 2026Article
- Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study.Journal of arrhythmia · 2026Article
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- Causal association between allergic diseases and short stature: a mendelian randomization study revealing the potential mediating role of inflammatory proteins.Jornal de pediatria · 2026Article
- Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals.Nature communications · 2026Article
- Polygenic risk scores and plasma proteomics identify cancer-related proteins and trans-regulated protein networks.Cell genomics · 2026Article
- Causal Effects of Oral Microbiome, Circulating Metabolites, and Inflammatory Proteins on Recurrent Aphthous Stomatitis: A Two-Sample Mendelian Randomization Study.Oral health & preventive dentistry · 2026Article
- Nat10-mediated acScience China. Life sciences · 2026Article
- Proteogenomics in human populations.Nature reviews. Genetics · 2026Review
- Macrophage Lipid Homeostasis Drives IVDD via a Senescence-Dependent Impairment of Efferocytosis.Cell proliferation · 2026Article
- Neuronal Cell-Specific sc-eQTL and Integrative eQTL-pQTL Mendelian Randomization Prioritize CKAP2 as a Candidate Gene for Major Depressive Disorder.Journal of molecular neuroscience : MN · 2026Observational
- Article
- Mendelian randomization analysis of inflammatory proteins and lung adenocarcinoma risk.Discover oncology · 2026Article
- C-X-C motif chemokine ligands (CXCL1/CXCL9) in inflammatory pathways underlying epilepsy-related ventricular remodeling: a mendelian randomization study.Acta neurologica Belgica · 2026Article
439 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
42 authors at 18 institutions in 7 countries.
Jing Hua Zhao *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
David Stacey *British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Niclas ErikssonUppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2152-4343
Erin Macdonald-DunlopCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6569-6086
Åsa K HedmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anette KalnapenkisBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Stefan EnrothDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-5056-9137
Domenico CozzettoDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6752-5432
Jonathan Digby-BellSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Jonathan MartenBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lasse FolkersenNucleus Genomics ltd, New York, NY, USA.ORCID http://orcid.org/0000-0003-0708-9530
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-2050-093X
Lina JonssonInstitute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Christian GiegerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Elise J NeedhamBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Praveen SurendranBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Estonian Biobank Research Team
Dirk S PaulBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8230-0116
Ozren PolasekMedical School, University of Split, Split, Croatia.
Barbara ThorandGerman Center for Diabetes Research, Munich-Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8416-6440
Harald GrallertGerman Center for Diabetes Research, Munich-Neuherberg, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-8200-6382
Urmo VõsaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Tonu EskoEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Åsa JohanssonDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2915-4498
Ulf GyllenstenDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6316-3355
Nick PowellDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-8467-7286
Niklas Mattsson-CarlgrenWallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.
Peter K JoshiCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Leonid PadyukovDivision of Rheumatology, Department of Medicine (Solna), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2950-5670
Lars KlareskogDivision of Rheumatology, Department of Medicine (Solna), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9601-6186
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4496-6451
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Agneta SiegbahnDepartment of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Lars WallentinDepartment of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Anders MälarstigDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2608-1358
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-6915-9015
James E PetersBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. j.peters@imperial.ac.uk.ORCID http://orcid.org/0000-0002-9415-3440
University of Tartu · EEUppsala University · SEUniversity of Cambridge · GBKarolinska Institutet · SEHelmholtz Zentrum München · DEDüsseldorf University Hospital · DEImperial College London · GBKarolinska University Hospital · SELund University · SENHS Blood and Transplant · GBUniversity of Edinburgh · GBWestern General Hospital · GBAstraZeneca (United Kingdom) · GBBritish Heart Foundation · GBKing's College London · GBUniversity of Gothenburg · SEUniversity of South Australia · AUUniversity of Split · HR
Funding
British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Chief Scientist Office CZB/4/710Medical Research Council MC_UU_00007/10Medical Research Council MR/L003120/1Medical Research Council MR/S003746/1MRF_ MRF-042-0001-RG-PETE-C0839MRF_ MRF-057-0003-RG-PETE-C0799
Abstract
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-α in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut CXCL5 transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization.
Indexed as
Colitis, UlcerativeInflammatory Bowel DiseasesMultiple SclerosisGenome-Wide Association StudyHumansInflammationPolymorphism, Single NucleotideQuantitative Trait Loci
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.