Evidence map›Paper›PMID 37563227›Full record

ArticleNature aging2023

Universal DNA methylation age across mammalian tissues.

A T Lu, Z Fei, A Haghani, T R Robeck, J A Zoller, C Z Li, R Lowe, Q Yan, J Zhang, H Vu and 178 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 290 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

290 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Transplanted hearts assimilate the recipient's biological age.bioRxiv : the preprint server for biology · 2026
    Article
  10. Evolutionary genetics of ageing.Nature reviews. Genetics · 2026
    Review
  11. Review
  12. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. [Systemic Reprogramming of Cellular Senescence: Coordinated Regulation of Metabolism, Epigenetics, and Proteostasis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  18. Article
  19. Article
  20. Article

230 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

188 authors.

A T Lu *Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2866-7961
Z Fei *Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
A HaghaniDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6052-8793
T R RobeckZoological SeaWorld Parks and Entertainment, Orlando, FL, USA.
J A ZollerDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6309-0291
C Z LiDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3907-7983
R LoweAltos Labs, Cambridge Institute of Science, Cambridge, UK.
Q YanAltos Labs, San Diego Institute of Science, San Diego, CA, USA.
J ZhangDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4488-1175
H VuBioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.
J AblaevaDepartment of Biology, University of Rochester, Rochester, NY, USA.
V A Acosta-RodriguezDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4818-0667
D M AdamsDepartment of Biology, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-8260-4064
J AlmuniaLoro Parque Fundacion, Puerto de la Cruz, Spain.ORCID http://orcid.org/0000-0001-6343-1463
A AloysiusDepartment of Biology, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-6705-4810
R ArdehaliDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
A ArnesonBioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.
C S BakerMarine Mammal Institute, Oregon State University, Newport, OR, USA.ORCID http://orcid.org/0000-0003-2183-2036
G BanksSchool of Science and Technology, Clifton Campus, Nottingham Trent University, Nottingham, UK.
K BelovSchool of Life and Environmental Sciences, the University of Sydney, Sydney, New South Wales, Australia.
N C BennettDepartment of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.
P BlackBusch Gardens Tampa, Tampa, FL, USA.
D T BlumsteinDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5793-9244
E K BorsMarine Mammal Institute, Oregon State University, Newport, OR, USA.
C E BreezeAltius Institute for Biomedical Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5294-915X
R T BrookeEpigenetic Clock Development Foundation, Los Angeles, CA, USA.
J L BrownCenter for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA, USA.
G G CarterDepartment of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.
A CaultonAgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.
J M CavinGulf World, Dolphin Company, Panama City Beach, FL, USA.
L ChakrabartiSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
I ChatzistamouDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA.
H ChenDepartment of Pharmacology, Addiction Science and Toxicology, the University of Tennessee Health Science Center, Memphis, TN, USA.
K ChengMedical Informatics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
P ChiavelliniBiochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina.
O W ChoiCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
S M ClarkeAgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.ORCID http://orcid.org/0000-0002-4615-8917
L N CooperDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, USA.ORCID http://orcid.org/0000-0002-1765-927X
M L CossetteDepartment of Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada.ORCID http://orcid.org/0000-0001-7215-0997
J DayTaronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9390-7506
J DeYoungCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
S DiRoccoSeaWorld of Florida, Orlando, FL, USA.
C DoldZoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA.
E E EhmkeDuke Lemur Center, Durham, NC, USA.
C K EmmonsConservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1326-3646
S EmmrichDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0537-4242
E ErbayAltos Labs, San Francisco, CA, USA.
C Erlacher-ReidSeaWorld of Florida, Orlando, FL, USA.
C G FaulkesSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5228-9075
S H FergusonFisheries and Oceans Canada, Freshwater Institute, Winnipeg, Manitoba, Canada.ORCID http://orcid.org/0000-0002-3794-0122
C J FinnoDepartment of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, CA, USA.
J E FlowerMystic Aquarium, Mystic, CT, USA.
J M GaillardUniversite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France.
E GardeGreenland Institute of Natural Resources, Nuuk, Greenland.
L GerberEvolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, UNSW Sydney, Sydney, New South Wales, Australia.
V N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0372-7016
V GorbunovaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-8979-0333
R G GoyaBiochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina.ORCID http://orcid.org/0000-0002-5469-5499
M J GrantApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand.
C B GreenDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
E N HalesDepartment of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, CA, USA.
M B HansonConservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA.
D W HartDepartment of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.ORCID http://orcid.org/0000-0002-4592-558X
M HaulenaVancouver Aquarium, Vancouver, British Columbia, Canada.
K HerrickSeaWorld of California, San Diego, CA, USA.
A N HoganCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
C J HoggSchool of Life and Environmental Sciences, the University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6328-398X
T A HoreDepartment of Anatomy, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-6735-225X
T HuangDivision of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0000-0001-6601-6687
J C Izpisua BelmonteAltos Labs, San Diego Institute of Science, San Diego, CA, USA.
A J JasinskaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1897-4570
G JonesSchool of Biological Sciences, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1904-3735
E JourdainNorwegian Orca Survey, Andenes, Norway.
O KashpurMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
H KatcherYuvan Research, Mountain View, CA, USA.
E KatsumataKamogawa Sea World, Kamogawa, Japan.
V KazaPeromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA.
H KiarisPeromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0002-8999-8289
M S KoborEdwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
P KordowitzkiInstitute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.ORCID http://orcid.org/0000-0002-3344-5060
W R KoskiLGL Limited, King City, Ontario, Canada.ORCID http://orcid.org/0000-0001-7426-9975
M KrützenEvolutionary Genetics Group, Department of Evolutionary Anthropology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1055-5299
S B KwonBioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.
B LarisonDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.
S G LeeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
M LehmannBiochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina.
J F LemaitreUniversite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France.ORCID http://orcid.org/0000-0001-9898-2353
A J LevineDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
C LiTexas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.
X LiTechnology Center for Genomics and Bioinformatics, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
A R LimDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
D T S LinCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
D M LindemannSeaWorld of Florida, Orlando, FL, USA.
T J LittleInstitute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
N MacorettaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
D MaddoxWhite Oak Conservation, Yulee, FL, USA.
C O MatkinNorth Gulf Oceanic Society, Homer, AK, USA.
J A MattisonTranslational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
M McClureABS Global, DeForest, WI, USA.
J MerglMarineland of Canada, Niagara Falls, Ontario, Canada.
J J MeudtBiomedical and Genomic Research Group, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA.
G A MontanoZoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA.
K MozhuiDepartment of Preventive Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6623-4112
J Munshi-SouthLouis Calder Center-Biological Field Station, Department of Biological Sciences, Fordham University, Armonk, NY, USA.
A NaderiDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0001-9911-5841
M NagyMuseum fur Naturkunde, Leibniz Institute for Evolution and Biodiversity Science, Berlin, Germany.ORCID http://orcid.org/0000-0002-9768-3930
P NarayanApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-8713-1470
P W NathanielszTexas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.
N B NguyenDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
C NiehrsInstitute of Molecular Biology, Mainz, Germany.
J K O'BrienTaronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia.
P O'Tierney GinnMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5752-4874
D T OdomCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
A G OphirDepartment of Psychology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-4877-9696
S OsbornSeaWorld of Texas, San Antonio, TX, USA.
E A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6075-9738
K M ParsonsConservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA.
K C PaulDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
M PellegriniDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
K J PetersEvolutionary Genetics Group, Department of Evolutionary Anthropology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5967-0928
A B PedersenInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
J L PetersenDepartment of Animal Science, University of Nebraska, Lincoln, NE, USA.ORCID http://orcid.org/0000-0001-5438-8555
D W PietersenMammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.ORCID http://orcid.org/0000-0002-7592-8319
G M PinhoDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4671-8221
J PlassaisCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2112-1595
J R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3098-8550
N A PradoDepartment of Biology, College of Arts and Science, Adelphi University, Garden City, NY, USA.
P ReddyAltos Labs, San Diego Institute of Science, San Diego, CA, USA.
B ReyUniversite de Lyon, Universite Lyon 1, CNRS, Laboratoire de Biometrie et Biologie Evolutive, Villeurbanne, France.ORCID http://orcid.org/0000-0002-0464-5573
B R RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6976-7339
J RobbinsCenter for Coastal Studies, Provincetown, MA, USA.ORCID http://orcid.org/0000-0002-6382-722X
M RodriguezMiami Seaquarium, Miami, FL, USA.
J RussellSeaWorld of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-0288-8392
E RydkinaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
L L SailerDepartment of Psychology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-2020-2390
A B SalmonThe Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, UT Health San Antonio and the Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-1475-7843
A SanghaviYuvan Research, Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-0219-0376
K M SchachtschneiderDepartment of Radiology, University of Illinois at Chicago, Chicago, IL, USA.
D SchmittCollege of Agriculture, Missouri State University, Springfield, MO, USA.ORCID http://orcid.org/0000-0003-0023-5427
T SchmittSeaWorld of California, San Diego, CA, USA.
L SchomacherInstitute of Molecular Biology, Mainz, Germany.ORCID http://orcid.org/0000-0002-3841-5258
L B SchookDepartment of Radiology, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6580-8364
K E SearsDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9744-9602
A W SeifertDepartment of Biology, University of Kentucky, Lexington, KY, USA.
A SeluanovDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-3400-538X
A B A ShaferDepartment of Forensic Science, Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada.
D ShanmuganayagamBiomedical and Genomic Research Group, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8882-1668
A V ShindyapinaDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
M SimmonsDuke Lemur Center, Durham, NC, USA.
K SinghShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS University, Mumbai, India.
I SinhaDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.
J SloneDivision of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA.
R G SnellApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, the University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-8166-4014
E SoltanmaohammadiDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
M L SpanglerDepartment of Animal Science, University of Nebraska, Lincoln, NE, USA.ORCID http://orcid.org/0000-0001-5184-501X
M C SpriggsBusch Gardens Tampa, Tampa, FL, USA.
L StaggsSeaWorld of Florida, Orlando, FL, USA.
N StedmanBusch Gardens Tampa, Tampa, FL, USA.
K J SteinmanSpecies Preservation Laboratory, SeaWorld San Diego, San Diego, CA, USA.
D T StewartBiology Department, Acadia University, Wolfville, Nova Scotia, Canada.
V J SugrueDepartment of Anatomy, University of Otago, Dunedin, New Zealand.
B SzladovitsDepartment of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK.ORCID http://orcid.org/0000-0002-1926-3455
J S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0384-8878
M TakasugiDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
E C TeelingSchool of Biology and Environmental Science, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3309-1346
M J ThompsonDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2914-1080
B Van BonnJohn G. Shedd Aquarium, Chicago, IL, USA.
S C VernesSchool of Biology, the University of St Andrews, Fife, UK.
D VillarBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-8614-6232
H V VintersDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
M C WallingfordMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
N WangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
R K WayneDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, USA.
G S WilkinsonDepartment of Biology, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0001-7799-8444
C K WilliamsDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
R W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA.
X W YangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3705-7935
M YaoDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
B G YoungFisheries and Oceans Canada, Winnipeg, Manitoba, Canada.ORCID http://orcid.org/0000-0001-7708-3981
B ZhangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Z ZhangDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
P ZhaoDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6610-6217
Y ZhaoDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
W ZhouCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J ZimmermannDepartment of Mathematics and Technology, University of Applied Sciences Koblenz, Koblenz, Germany.ORCID http://orcid.org/0000-0002-7667-5616
J ErnstBioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4026-7853
K Raj *Altos Labs, Cambridge Institute of Science, Cambridge, UK.ORCID http://orcid.org/0000-0002-3744-265X
S Horvath *Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-4110-3589

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI Jef D BOEKE · 2016 to 2026
$30.4M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
The role of mTOR inhibition on longevity and healthy aging in a non-human primateR01AG050797 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2015 to 2019
$2.7M
Characterization of Marmosets as a Geroscience Model by the San Antonio MAPU34AG068482 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ROSS, CORINNA NICOLE, SALMON, ADAM · 2020 to 2022
$1.4M
DNA methylation and gene expression study of aging and lifespan differencesR21AG055841 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MOZHUI, KHYOBENI · 2017 to 2018
$418k
Lymph node regulation of metastatic fitness and reemergenceK00CA234840 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIM, ANDREA RACHEL · 2021 to 2023
$164k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
Medical Research Council MR/T021985/1NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS N01 HC025195NIA NIH HHS U01 AG060908
6 · The paper itself

Abstract

Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.

Indexed as

DNA MethylationEpigenesis, GeneticAgingAnimalsHumansLongevityMammalsMice

Identifiers

PMID37563227
PMCPMC10501909

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