ArticleNature communications2023
In situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Molecularly Imprinted Polymers for Biosensing: From Synthetic Recognition to Integrated Biointerfaces.Micromachines · 2026Review
- A molecularly imprinted electrochemical sensor co-modified with palladium-metallene and graphene nanoribbons for the detection of zearalenone.Mikrochimica acta · 2026Article
- From biomolecular condensates to functional nanomaterials: LLPS-inspired frameworks for nanoscale hydrogels and adaptive materials.Journal of nanobiotechnology · 2026Review
- Crossing the Blood-Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Development of molecularly imprinted vegetarian membranes (MIP-VMs) for oral tissue repair and regeneration.Frontiers in bioengineering and biotechnology · 2026Article
- Lysozyme detection in body biofluids by dual-decorated graphene oxide-gold nanoparticles-based biomimetic plasmonic sensor.Mikrochimica acta · 2025Article
- Review
- Recent Progress of Molecularly Imprinted Technique for the Detection of Mycotoxins in Food.Foods (Basel, Switzerland) · 2024Review
- Article
- Sensing with Molecularly Imprinted Membranes on Two-Dimensional Solid-Supported Substrates.Sensors (Basel, Switzerland) · 2024Review
- Advancing 3D printed microfluidics with computational methods for sweat analysis.Mikrochimica acta · 2024Review
- Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.Frontiers in cellular and infection microbiology · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current practices in synthesizing molecularly imprinted polymers face challenges-lengthy process, low-productivity, the need for expensive and sophisticated equipment, and they cannot be controlled in situ synthesis. Herein, we present a micro-reactor for in situ and continuously synthesizing trillions of molecularly imprinted polymeric nanoparticles that contain molecular fingerprints of bovine serum albumin in a short period of time (5-30 min). Initially, we performed COMSOL simulation to analyze mixing efficiency with altering flow rates, and experimentally validated the platform for synthesizing nanoparticles with sizes ranging from 52-106 nm. Molecular interactions between monomers and protein were also examined by molecular docking and dynamics simulations. Afterwards, we benchmarked the micro-reactor parameters through dispersity and concentration of molecularly imprinted polymers using principal component analysis. Sensing assets of molecularly imprinted polymers were examined on a metamaterial sensor, resulting in 81% of precision with high selectivity (4.5 times), and three cycles of consecutive use. Overall, our micro-reactor stood out for its high productivity (48-288 times improvement in assay-time and 2 times improvement in reagent volume), enabling to produce 1.4-1.5 times more MIPs at one-single step, and continuous production compared to conventional strategy.
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