Evidence map›Paper›PMID 37563130›Full record

ArticleNature communications2023

Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis.

Ariel C Vonk, Xiaofan Zhao, Zheyu Pan, Megan L Hudnall, Conrad G Oakes, Gabriela A Lopez, Sarah C Hasel-Kolossa, Alexander W C Kuncz, Sasha B Sengelmann, Darian J Gamble and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Macrophages orchestrate tail regeneration in lizardsFrontiers in cell and developmental biology · 2026
    Article
  6. Spatial multi-omics reveals the potential involvement of SPP1Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ariel C VonkDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA.ORCID 0000-0002-8739-8407
Xiaofan ZhaoMolecular Genomics Core, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA.
Zheyu PanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA.ORCID 0000-0002-9509-0154
Megan L HudnallDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Los Angeles, CA, 90033, USA.
Conrad G OakesDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Los Angeles, CA, 90033, USA.ORCID 0000-0002-8936-055X
Gabriela A LopezDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA.
Sarah C Hasel-KolossaDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA.ORCID 0000-0002-6030-5506
Alexander W C KunczDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Los Angeles, CA, 90033, USA.ORCID 0000-0001-5740-9753
Sasha B SengelmannDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1540 Alcazar St, Los Angeles, CA, 90033, USA.
Darian J GambleDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA.
Thomas P LozitoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1425 San Pablo St, Los Angeles, CA, 90033, USA. lozito@usc.edu.ORCID 0000-0002-6855-3571
University of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Why Don’t Lizards Regenerate Perfect Tails Like Salamanders?R01GM115444 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LOZITO, THOMAS PETER · 2016 to 2025
$3.3M
Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
NCI NIH HHS P30 CA014089NICHD NIH HHS T32 HD060549NIGMS NIH HHS R01 GM115444
6 · The paper itself

Abstract

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema formation and chondrogenesis remain unclear. Here, single-cell RNA sequencing analysis of regenerating lizard tails identifies fibroblast and phagocyte populations linked to cartilage formation. Pseudotime trajectory analyses suggest spp1

Indexed as

Hedgehog ProteinsLizardsAnimalsChondrogenesisFibroblastsHumansMammalsSingle-Cell AnalysisTailHedgehog Proteins

Identifiers

PMID37563130
PMCPMC10415409
OpenAlexW4385720579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.