Evidence map›Paper›PMID 37563050›Full record

ArticleVaccine2023

Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates.

Melanie J Shears, Felicia N Watson, Brad C Stone, Irene Cruz Talavera, Chaitra Parthiban, Jokichi Matsubara, Natasha Kc, B Kim Lee Sim, Stephen L Hoffman, Sean C Murphy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Melanie J ShearsDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States. Electronic address: mshears@uw.edu.
Felicia N WatsonDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Brad C StoneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Irene Cruz TalaveraDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Chaitra ParthibanDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Jokichi MatsubaraDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Natasha KcSanaria Inc., Rockville, MD, United States.
B Kim Lee SimSanaria Inc., Rockville, MD, United States.
Stephen L HoffmanSanaria Inc., Rockville, MD, United States.
Sean C MurphyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States; Department of Microbiology, University of Washington, Seattle, WA, United States; Washington National Primate Research Center, University of Washington, Seattle, WA, United States. Electronic address: murphysc@uw.edu.
University of Washington · USSanaria · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI CHARLOTTE HOTCHKISS · 2012 to 2026
$34.4M
Liver resident memory for malariaR01AI141857 · NIAID · UNIVERSITY OF WASHINGTON · PI MURPHY, SEAN C · 2019 to 2023
$3.9M
A Pilot Study to Evaluate Plasmodium falciparum Liver-Stage Challenge in Prime-and-Trap Vaccinated Rhesus MonkeysR03AI144143 · NIAID · UNIVERSITY OF WASHINGTON · PI MURPHY, SEAN C · 2019 to 2020
$176k
NIAID NIH HHS R01 AI141857NIAID NIH HHS R03 AI144143NIH HHS P51 OD010425NIH HHS U42 OD011123
6 · The paper itself

Abstract

Development of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding CSP followed by a single dose of attenuated SPZ. This strategy aims to induce CD8

Indexed as

Malaria, FalciparumMalaria VaccinesAnimalsAntibodies, ProtozoanCD8-Positive T-LymphocytesMacaca mulattaMicePlasmodium falciparumProtozoan ProteinsVaccines, AttenuatedAntibodies, ProtozoanMalaria VaccinesProtozoan ProteinsVaccines, AttenuatedMacaqueMalariaVaccine

Identifiers

PMID37563050
PMCPMC10528330
OpenAlexW4385659689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.