Evidence map›Paper›PMID 37562951›Full record

ArticleJournal of cachexia, sarcopenia and muscle2023

Association between the 110-kDa C-terminal agrin fragment and skeletal muscle decline among community-dwelling older women.

Kuniyasu Kamiya, Takahiro Tachiki, Yuho Sato, Katsuyasu Kouda, Etsuko Kajita, Junko Tamaki, Sadanobu Kagamimori, Masayuki Iki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Kuniyasu KamiyaDepartment of Hygiene and Public Health, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.ORCID 0000-0002-1727-4214
Takahiro TachikiFaculty of Nursing, Chukyo Gakuin University, Mizunami, Japan.
Yuho SatoDepartment of Human Life, Jin-ai University, Echizen, Japan.
Katsuyasu KoudaDepartment of Hygiene and Public Health, Kansai Medical University, Hirakata, Japan.
Etsuko KajitaFaculty of Nursing, Chukyo Gakuin University, Mizunami, Japan.
Junko TamakiDepartment of Hygiene and Public Health, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Sadanobu KagamimoriUniversity of Toyama, Toyama, Japan.
Masayuki IkiDepartment of Public Health, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
Chukyo Gakuin University · JPOsaka University of Pharmaceutical Sciences · JPJin-ai University · JPKansai Medical University · JPKindai University · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC-terminal agrin fragment (CAF) is a biomarker for neuromuscular junction degradation. This study aimed to investigate whether 110-kDa CAF (CAF110) was associated with the presence and incidence of low muscle mass and strength.

methodsThis cross-sectional retrospective cohort study comprised women aged ≥65 years. We measured muscle mass using a dual-energy X-ray absorptiometry scanner, hand-grip strength, and blood sampling between 2011 and 2012. A follow-up study with the same measurements was conducted between 2015 and 2017. Low muscle mass and strength were defined as an appendicular skeletal muscle mass index <5.4 kg/m

resultsIn total, 515 women (74.3 ± 6.3 years) were included in this cross-sectional analysis. Of these, 101 (19.6%) and 128 (24.9%) women presented with low muscle mass and strength, respectively. For low muscle mass, the odds ratios (ORs) of the middle and highest CAF110 tertile groups, compared with the lowest group, were 1.93 (95% confidence interval: 1.09-3.43; P = 0.024) and 2.15 (1.22-3.80; P = 0.008), respectively. After adjusting for age, the ORs remained significant: 1.98 (1.11-3.52; P = 0.020) and 2.27 (1.28-4.03; P = 0.005), respectively. Low muscle strength ORs of all the CAF110 tertile groups were not significant. In the longitudinal analysis, 292 and 289 women were assessed for incidents of low muscle mass and strength, respectively. Of those, 34 (11.6%) and 20 (6.9%) women exhibited low muscle mass and strength, respectively. For incident low muscle mass, the crude OR of the CAF110 ≥ the median value group was marginally higher than that of the CAF110 < median value group (median [interquartile range]: 1.98 [0.94-4.17] (P = 0.072). After adjusting for age and baseline muscle mass, the OR was 2.22 [0.97-5.06] (P = 0.058). All low muscle strength ORs of the median categories of CAF110 were not significant.

conclusionsCAF110 was not associated with low muscle strength. However, CAF110 may be a potential marker for the incidence of low muscle mass.

Indexed as

AgingIndependent LivingAgedAgrinCross-Sectional StudiesFemaleFollow-Up StudiesHumansMuscle, SkeletalPeptide FragmentsRetrospective StudiesAgrinC-terminal agrin fragmentPeptide FragmentsAgingAgrinBiomarkerNeuromuscular junction

Identifiers

PMID37562951
PMCPMC10570065
OpenAlexW4385717917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.