ArticleAJNR. American journal of neuroradiology2023
Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog.
Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Multimodal Imaging-Based Cerebral Blood Flow Prediction Model Development in Simulated Microgravity.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension: Can Anemia and Hyperemia Underlie Both?AJNR. American journal of neuroradiology · 2024Article
- Reply.AJNR. American journal of neuroradiology · 2024Article
- Enlargement of Perivascular Spaces as a Downstream Consequence of Spaceflight Analog-Induced Alterations in Cerebral Venous Hemodynamics.AJNR. American journal of neuroradiology · 2024Article
- Reply.AJNR. American journal of neuroradiology · 2024Article
- A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue.NPJ microgravity · 2024Review
- Neurocognitive Adaptations for Spatial Orientation and Navigation in Astronauts.Brain sciences · 2023Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeA global decrease in brain perfusion has recently been reported during exposure to a ground-based spaceflight analog. Considering that CSF and glymphatic flow are hypothesized to be propelled by arterial pulsations, it is unknown whether a change in perfusion would impact these CSF compartments. The aim of the current study was to evaluate the relationship among changes in cerebral perfusion, ventricular volume, and perivascular space volume before, during, and after a spaceflight analog. MATERIALS AND
methodsEleven healthy participants underwent 30 days of bed rest at 6° head-down tilt with 0.5% atmospheric CO
resultsGlobal perfusion followed a divergent time trajectory from ventricular and perivascular space volume, with perfusion decreasing during the analog, whereas ventricular and perivascular space volume increased (
conclusionsThe patterns of change in brain physiology observed in healthy participants suggest a relationship between cerebral perfusion and CSF homeostasis. Further study is warranted to determine whether a causal relationship exists and whether similar neurophysiologic responses occur during spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.