Evidence map›Paper›PMID 37561727›Full record

ArticlePloS one2023

Effect of the COVID-19 lockdown on the HIV care continuum in Southwestern Uganda: A time series analysis.

Jane Kabami, Asiphas Owaraganise, Brian Beesiga, Jaffer Okiring, Elijah Kakande, Yea-Hung Chen, Florence Mwangwa, Cecilia Akatukwasa, Joanita Nangendo, Winnie Muyindike and 3 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jane KabamiInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.ORCID 0000-0002-0265-3174
Asiphas OwaraganiseInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.ORCID 0000-0002-5594-0310
Brian BeesigaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Jaffer OkiringInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Elijah KakandeInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.ORCID 0000-0001-9532-5710
Yea-Hung ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.
Florence MwangwaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Cecilia AkatukwasaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Joanita NangendoDepartment of Medicine, Makerere University, Kampala, Uganda.
Winnie MuyindikeGlobal Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.ORCID 0000-0002-6694-2645
Fred C SemitalaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Michelle E RohDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America.
Moses R KamyaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Infectious Diseases Research Collaboration · UGUniversity of California, San Francisco · USMakerere University · UGMbarara University of Science and Technology · UG

Funding

Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in UgandaD43TW010037 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KAMYA, MOSES ROBERT, SEMITALA, FRED C · 2015 to 2025
$3.3M
FIC NIH HHS D43 TW010037
6 · The paper itself

Abstract

introductionIn Uganda, COVID-19 lockdown policies curbed the spread of SARS-CoV-2, but their effect on HIV care is poorly understood.

objectivesWe examined the effects of COVID-19 lockdown policies on ART initiation, missed visits, and viral suppression in Uganda.

methodsWe conducted a time series analysis using data from a dynamic cohort of persons with HIV enrolled between March 2017 and September 2021 at HIV clinics in Masaka and Mbarara Regional Referral Hospitals in Southwestern Uganda. Poisson and fractional probit regression were used to predict expected monthly antiretroviral therapy initiations, missed visits, and viral suppression based on pre-lockdown trends. Observed and expected trends were compared across three policy periods: April 2020-September 2021 (overall), April-May 2020 (1st lockdown), and June-August 2021 (2nd lockdown).

resultsWe enrolled 7071 Persons living with HIV (PWH) (nMasaka = 4150; nMbarara = 2921). Average ART duration was 34 and 30 months in Masaka and Mbarara, respectively. During the 18-month post-lockdown period, monthly ART initiations were lower than expected in both Masaka (51 versus 63 visits; a decrease of 12 [95% CI: -2, 31] visits) and Mbarara (42 versus 55 visits; a decrase of 13 [95% CI: 0, 27] visits). Proportion of missed visits was moderately higher than expected post-lockdown in Masaka (10% versus 7%; 4% [95% CI: 1%, 7%] absolute increase), but not in Mbarara (13% versus 13%; 0% [95% CI: -4%, 6%] absolute decrease). Viral suppression rates were moderate-to-high in Masaka (64.7%) and Mbarara (92.5%) pre-lockdown and remained steady throughout the post-lockdown period.

conclusionThe COVID-19 lockdown in Uganda was associated with reductions in ART initiation, with minimal effects on retention and viral suppression, indicating a resilient HIV care system.

Indexed as

COVID-19HIV InfectionsCommunicable Disease ControlContinuity of Patient CareHumansSARS-CoV-2Time FactorsUganda

Identifiers

PMID37561727
PMCPMC10414556
OpenAlexW4385732697

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.