Evidence map›Paper›PMID 37561343›Full record

ArticleAnnals of surgical oncology2023

The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: Epithelial Ovarian Cancer.

Aditi Bhatt, Olivier Glehen, Oliver Zivanovic, Donal Brennan, Cedric Nadeau, Willemien Van Driel, Naoual Bakrin

Abstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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  16. Review of 2022 PSOGI/RENAPE Consensus on HIPEC.Journal of surgical oncology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Aditi BhattDepartment of Surgical Oncology, KD Hospital, Ahmedabad, India. aditimodi31@gmail.com.ORCID http://orcid.org/0000-0002-9808-6898
Olivier GlehenDepartment of Surgical Oncology, Centre Hospitalier, Lyon-sud, Lyon, France.
Oliver ZivanovicDepartment of Gynecological Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Donal BrennanUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
Cedric NadeauDepartment of Gynecological Oncology, CHU de Poitiers, Poitiers, Cedex, France.
Willemien Van DrielDepartment of Gynecological Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Naoual BakrinDepartment of Surgical Oncology, Centre Hospitalier, Lyon-sud, Lyon, France.
Hôpital Lyon Sud · FRAhmedabad Civil Hospital · INCentre Hospitalier Universitaire de Poitiers · FRMater Misericordiae University Hospital · IEMemorial Sloan Kettering Cancer Center · USThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimWe report the results of an international consensus on hyperthermic intraperitoneal chemotherapy (HIPEC) regimens for epithelial ovarian cancer (EOC) performed with the following goals: To define the indications for HIPEC To identify the most suitable HIPEC regimens for each indication in EOC To identify areas of future research on HIPEC To provide recommendations for some aspects of perioperative care for HIPEC

methodsThe Delphi technique was used with two rounds of voting. There were three categories of questions: evidence-based recommendations [using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system with the patient, intervention, comparator, and outcome (PICO) method], an opinion survey, and research recommendations.

resultsSeventy-three (67.5%) of 108 invited experts responded in round I, and 68 (62.9%) in round II. Consensus was achieved for 34/38 (94.7%) questions. However, a strong positive consensus that would lead to inclusion in routine care was reached for only 6/38 (15.7%) questions. HIPEC in addition to interval cytoreductive surgery (CRS) received a strong positive recommendation that merits inclusion in routine care. Single-agent cisplatin was the only drug recommended for routine care, and OVHIPEC-1 was the most preferred regimen. The panel recommended performing HIPEC for a minimum of 60 min with a recommended minimum intraabdominal temperature of 41°C. Nephroprotection with sodium thiosulfate should be used for cisplatin HIPEC.

conclusionsThe results of this consensus should guide clinical decisions on indications of HIPEC and the choice and various parameters of HIPEC regimens and could fill current knowledge gaps. These outcomes should be the basis for designing future clinical trials on HIPEC in EOC.

Indexed as

Hyperthermia, InducedOvarian NeoplasmsPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Ovarian EpithelialCisplatinCombined Modality TherapyCytoreduction Surgical ProceduresFemaleHumansHyperthermic Intraperitoneal ChemotherapyCisplatinAdvanced ovarian cancerEpithelial ovarian cancerHIPECInterval cytoreductive surgeryRecurrent ovarian cancer

Identifiers

PMID37561343
OpenAlexW4385715923

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.