Evidence map›Paper›PMID 37561269›Full record

Observational studyObesity surgery2023

Trajectory of Gonadal Hormones in Adolescent Males up to 2 Years After Sleeve Gastrectomy.

Snimarjot Kaur, Miriam A Bredella, Madhusmita Misra, Vibha Singhal

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02557438 (Bone Metabolism in Adolescents Undergoing Bariatric Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02557438 active not recruitingnot on this map

Bone Metabolism in Adolescents Undergoing Bariatric Surgery

TypeobservationalSponsorMassachusetts General HospitalRan2015 to 2027Enrolled240ConditionsObesity, SurgeryArmsRoux-en-Y Gastric Bypass, Vertical Sleeve Gastrectomy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Snimarjot KaurNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Boston, MA, 02114, USA.
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Boston, MA, 02114, USA.
Vibha SinghalNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Boston, MA, 02114, USA. vsinghal1@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9729-4433
Harvard University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Bone Metabolism in Adolescents Undergoing Bariatric SurgeryR01DK103946 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE, MISRA, MADHUSMITA · 2015 to 2019
$3.2M
Determinants of Beta Cell Function Following Sleeve Gastrectomy in AdolescentsK23DK110419 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SINGHAL, VIBHA · 2016 to 2021
$1.1M
Bone Metabolism in Adolescents UndergoingBariatric SurgeryK24DK109940 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE · 2017 to 2021
$970k
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
NICHD NIH HHS K24 HD071843NIDDK NIH HHS K23 DK110419NIDDK NIH HHS K24 DK109940NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK103946
6 · The paper itself

Abstract

Sleeve gastrectomy (SG) has many metabolic benefits and leads to improvements in testosterone levels, which means improvement in the Leydig cell function of the testis. However, data about the effects of SG on Sertoli cell function (as assessed by inhibin B) are not available. In this preliminary study, we evaluate, for the first time, the effect of SG in adolescents after SG. We evaluate 16 adolescent and young adult males, six of whom underwent SG and followed them for 2 years. We report that Leydig cell function (as assessed by testosterone levels) improved and was associated with degree of weight loss. Sertoli cell function improved only slightly in SG group and did not change compared to the nonsurgical controls, and these changes were not associated with degree of weight loss. Thus, we conclude that larger and long-term follow-up studies are required to evaluate the changes in Sertoli cell function after SG as that is integral to male fertility.Clinical Trial Registration: NCT02557438.

Indexed as

Gastric BypassObesity, MorbidAdolescentGastrectomyGonadal HormonesHumansMaleTestosteroneWeight LossYoung AdultGonadal HormonesTestosteroneAdolescentsBariatric surgeryHypogonadismLeydig cellMalesSertoli cellSleeve gastrectomy

Identifiers

PMID37561269
OpenAlexW4385716233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.