ArticleAmerican journal of physiology. Renal physiology2023
Impact of sleep on chronobiology of micturition among healthy older adults.
Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Deciphering Sleepless Nights: Nocturia Analyzed Through a CART-Based Predictive Model in Patients With Insomnia. Retrospective Data From the TUCSON Study.Neurourology and urodynamics · 2026Observational
- Age and Nocturnal Polyuria in Nocturia: A Multicenter Voiding Diary Cohort Study.Neurourology and urodynamics · 2026Observational
- Sleep Health, Perceived Stress, and Urinary Incontinence Severity Among Women Veterans in the USA.International urogynecology journal · 2026Article
- Excessive daytime sleepiness is independently associated with dehydration among older adults.BMC geriatrics · 2026Article
- Association between physical activity intensity and nocturia risk: the mediating role of mental health.Journal of health, population, and nutrition · 2026Article
- Endogenous vasopressin and vasopressin receptor 2 in bladder as anti-diuretic / anti-spasmodic targets for the treatment of multifactorial nocturia.Continence (Amsterdam, Netherlands) · 2025Article
- The Chronobiology of Hormone Administration: "Doctor, What Time Should I Take My Medication?"Endocrine reviews · 2025Review
- Editorial Comment: Adjustment to an Appropriate Bedtime Improves Nocturia in Older Adults: A Crossover Study.International journal of urology : official journal of the Japanese Urological Association · 2025Article
- The mediating effect of sleep quality in the relationship between nocturia and psychosocial functions in nurses: a cross-sectional survey based on TARGET.BMC nursing · 2025Article
- Association between nocturia and sleep issues, incorporating the impact of lifestyle habits perceived as promoting sleep in an internet survey.Scientific reports · 2025Article
- Inflammation and vasopressin hypersecretion in aging.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Nocturia (waking to void) is prevalent among older adults. Disruption of the well-described circadian rhythm in urine production with higher nighttime urine output is its most common cause. In young adults, their circadian rhythm is modulated by the 24-h secretory pattern of hormones that regulate salt and water excretion, including antidiuretic hormone (ADH), renin, angiotensin, aldosterone, and atrial natriuretic peptide (ANP). The pattern of hormone secretion is less clear in older adults. We investigated the effect of sleep on the 24-h secretion of these hormones in healthy older adults. Thirteen participants aged ≥65 yr old underwent two 24-h protocols at a clinical research center 6 wk apart. The first used a habitual wake-sleep protocol, and the second used a constant routine protocol that removed the influence of sleep, posture, and diet. To assess hormonal rhythms, plasma was collected at 8:00 am, 12:00 pm, 4:00 pm, and every 30 min from 7:00 pm to 7:00 am. A mixed-effects regression model was used to compare subject-specific and mean trajectories of hormone secretion under the two conditions. ADH, aldosterone, and ANP showed a diurnal rhythm that peaked during sleep in the wake-sleep protocol. These nighttime elevations were significantly attenuated within subjects during the constant routine. We conclude that sleep has a masking effect on circadian rhythm amplitude of ADH, aldosterone, and ANP: the amplitude of each is increased in the presence of sleep and reduced in the absence of sleep. Disrupted sleep could potentially alter nighttime urine output in healthy older adults via this mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.