Evidence map›Paper›PMID 37560512›Full record

ArticlePhysics and imaging in radiation oncology2023

Dose evaluation of inter- and intra-fraction prostate motion in extremely hypofractionated intensity-modulated proton therapy for prostate cancer.

Sen-Quan Feng, Charlotte L Brouwer, Erik W Korevaar, Neha Vapiwala, Ken Kang-Hsin Wang, Curtiland Deville, Johannes A Langendijk, Stefan Both, Shafak Aluwini

Open access · goldAbstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sen-Quan FengDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Charlotte L BrouwerDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Erik W KorevaarDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Neha VapiwalaDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Ken Kang-Hsin WangBiomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Curtiland DevilleDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johannes A LangendijkDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stefan BothDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Shafak AluwiniDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLJohns Hopkins University · USThe University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · US

Funding

X-ray/optical tomographic guidance and assessment for pre-clinical radiation ResearchR37CA230341 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, KEN KANG-HSIN · 2019 to 2025
$2.2M
Quantitative bioluminescence tomography for pre-clinical radiotherapy researchR01CA240811 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, KEN KANG-HSIN · 2019 to 2023
$1.3M
NCI NIH HHS R01 CA240811NCI NIH HHS R37 CA230341
6 · The paper itself

Abstract

Inter- and intra-fractional prostate motion can deteriorate the dose distribution in extremely hypofractionated intensity-modulated proton therapy. We used verification CTs and prostate motion data calculated from 1024 intra-fractional prostate motion records to develop a voxel-wise based 4-dimensional method, which had a time resolution of 1 s, to assess the dose impact of prostate motion. An example of 100 fractional simulations revealed that motion had minimal impact on planning dose, the accumulated dose in 95 % of the scenarios fulfilled the clinical goals for target coverage (D95 > 37.5 Gy). This method can serve as a complementary measure in clinical setting to guarantee plan quality.

Indexed as

Extreme hypofractionationIntensity-modulated proton therapyProstate inter- and intra-fraction motionStereotactic body proton therapyUltra-hypofractionation

Identifiers

PMID37560512
PMCPMC10407426
OpenAlexW4385076553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.