Evidence map›Paper›PMID 37560413›Full record

ArticleNanoscale advances2023

SARS-CoV-2 virus-like-particles

Sarah McColman, Klaidi Shkalla, Pavleen Sidhu, Jady Liang, Selena Osman, Norbert Kovacs, Zainab Bokhari, Ana Carolina Forjaz Marques, Yuchong Li, Qiwen Lin and 2 more

Abstract read
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah McColmanDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.ORCID https://orcid.org/0000-0002-0236-6116
Klaidi ShkallaDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.ORCID https://orcid.org/0009-0006-0679-5379
Pavleen SidhuDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.
Jady LiangKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto Toronto ON Canada.ORCID https://orcid.org/0000-0001-9228-4407
Selena OsmanDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.
Norbert KovacsDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.
Zainab BokhariDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.
Ana Carolina Forjaz MarquesDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.
Yuchong LiKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto Toronto ON Canada.
Qiwen LinKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto Toronto ON Canada.
Haibo ZhangKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto Toronto ON Canada.ORCID https://orcid.org/0000-0002-1714-3038
David T CrambDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University Toronto ON Canada sarah.mccolman@torontomu.ca.ORCID https://orcid.org/0000-0003-2494-0091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 virus, implicated in the COVID-19 pandemic, recognizes and binds host cells using its spike glycoprotein through an angiotensin converting enzyme 2 (ACE-2) receptor-mediated pathway. Recent research suggests that spatial distributions of the spike protein may influence viral interactions with target cells and immune systems. The goal of this study has been to develop a liposome-based virus-like particle (VLP) by reconstituting the SARS-CoV-2 spike glycoprotein within a synthetic nanoparticle membrane, aiming to eventually establish tunability in spike protein presentation on the nanoparticle surface. Here we report on first steps to this goal, wherein liposomal SARS-CoV-2 VLPs were successfully produced

Identifiers

PMID37560413
PMCPMC10408587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.