Evidence map›Paper›PMID 37560214›Full record

ArticleAmerican journal of translational research2023

Knockdown of microRNA-96-5p resists oxidative stress-induced apoptosis in nucleus pulposus cells.

Ji Wang, Ziming Xia, Zhengyi Su, Hong Xue, Chengjun Huang, Ming Su

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ji WangDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.
Ziming XiaDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.
Zhengyi SuDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.
Hong XueDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.
Chengjun HuangDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.
Ming SuDepartment of Pain, Liuzhou Traditional Chinese Medical Hospital of Guangxi University of Chinese Medicine Liuzhou, Guangxi, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntervertebral disc degeneration (IVDD) often leads to low back pain, which severely affects people's quality of life. Oxidative stress (OS) can accelerate nucleus pulposus cell (NPCs) senescence and apoptosis. Exploring the mechanism underlying OS-induced apoptosis is of utmost importance to aid in the development of IVDD treatment.

methodsIn the current study, we tested the function of microRNA-96-5p in H

resultsH

conclusionsCollectively, knockdown of microRNA-96-5p enhanced PINK1/Parkin-mediated mitophagy by up-regulating FOXO1. Our results facilitate the understanding of the role of microRNA-96-5p in IVDD and the mechanism of H

Indexed as

FOXO1intervertebral disc degenerationMicroRNA-96-5pmitophagynucleus pulposus cells

Identifiers

PMID37560214
PMCPMC10408537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.