Evidence map›Paper›PMID 37560199›Full record

ArticleBioactive materials2023

Rational design of oral drugs targeting mucosa delivery with gut organoid platforms.

Tianjian Tong, Yijun Qi, Derrick Rollins, Luke D Bussiere, Debarpan Dhar, Cathy L Miller, Chenxu Yu, Qun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Review on Advancement of AI in Cell Engineering and Molecular Biology.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tianjian TongDepartment of Agricultural Biosystem and Engineering, Iowa State University, Ames, IA, USA.
Yijun QiDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Derrick RollinsDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Luke D BussiereDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Debarpan DharDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Cathy L MillerDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Chenxu YuDepartment of Agricultural Biosystem and Engineering, Iowa State University, Ames, IA, USA.
Qun WangDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Iowa State University · US

Funding

Rational Design of Oral Drugs Targeting Mucosa DeliveryR21EB032991 · NIBIB · IOWA STATE UNIVERSITY · PI WANG, QUN · 2022 to 2024
$612k
NIBIB NIH HHS R21 EB032991
6 · The paper itself

Abstract

Effective oral drugs and vaccines require high delivery efficiency across the gastrointestinal epithelia and protection of medically effective payloads (i.e., immunogens) against gastric damage. In this study, hollowed nanocarriers (NCs: silica nanospheres and gold nanocages) with poly-l-lysine (PLL) coating and mammalian orthoreovirus cell attachment protein σ1 functionalization (NC-PLL-σ1) were explored as functional oral drug delivery vehicles (ODDVs). The transport of these ODDVs to mucosal lymphoid tissues could be facilitated by microfold cells (M-cells) mediated transcytosis (via σ1-α2-3-linked sialic acids adherence) across gastrointestinal epithelia. PLL coating provided protection and slow-release of rhodamine 6 G (R6G), a model payload. The transport effectiveness of these ODDVs was tested on intestinal organoid monolayers

Indexed as

Biomimetic virusGold and silica nanoparticlesOral drug delivery vehiclesOrganoidsSigma 1 protein

Identifiers

PMID37560199
PMCPMC10406959
OpenAlexW4385323615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.