Evidence map›Paper›PMID 37560112›Full record

ArticleFrontiers in cardiovascular medicine2023

Changes in carotid artery texture by ultrasound and elastin features in a murine model.

Carol Mitchell, Rashid Al Mukaddim, Yuming Liu, Melissa Graham, Jens C Eickhoff, Ashley M Weichmann, Matthew C Tattersall, Claudia E Korcarz, James H Stein, Tomy Varghese and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carol MitchellDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Rashid Al MukaddimDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States.
Yuming LiuCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, United States.
Melissa GrahamComparative Pathology Laboratory, Research Animal Resources and Compliance, University of Wisconsin-Madison, Madison, WI, United States.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States.
Ashley M WeichmannCarbone Cancer Center, Small Animal Imaging and Radiotherapy Facility, University of Wisconsin-Madison, Madison, WI, United States.
Matthew C TattersallDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Claudia E KorcarzDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
James H SteinDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Tomy VargheseDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States.
Kevin W EliceiriDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Quantitative histopathology for cancer prognosis using quantitative phase imaging on stained tissuesR01CA238191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANASTASIO, MARK A, ELICEIRI, KEVIN WILLIAM · 2019 to 2023
$3.1M
Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingR01HL147866 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2020 to 2023
$2.9M
Ultrasonic and Photoacoustic Imaging System for Cancer & Cardiovascular ResearchS10OD018505 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2015 to 2015
$908k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA238191NHLBI NIH HHS R01 HL147866NIH HHS S10 OD018505
6 · The paper itself

Abstract

Objective: In humans, arterial grayscale ultrasound texture features independently predict adverse cardiovascular disease (CVD) events and change with medical interventions. We performed this study to examine how grayscale ultrasound texture features and elastin fibers change in plaque-free segments of the arterial wall in a murine model prone to atherosclerosis. Methods: A total of 10 Apoe Results: Arterial wall homogeneity changed significantly in male mice from 6 to 24 weeks, with a mean (SD) of 0.14 (0.03) units at 6 weeks and 0.18 (0.03) units at 24 weeks ( Conclusion: Grayscale ultrasound texture features that are associated with increased risk for CVD events in humans were used in a murine model, and the grayscale texture feature SGLD-HOM was shown to change in male mice from 6 weeks to 24 weeks. Structural alterations of the arterial wall (change in elastin fiber number) were observed during this time and may differ by sex.

Indexed as

atherosclerosiscarotidelastin quantificationpre-clinical murine modeltexture featuresultrasound imaging

Identifiers

PMID37560112
PMCPMC10407807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.