Evidence map›Paper›PMID 37559998›Full record

ArticleAmerican journal of cancer research2023

TPM3: a novel prognostic biomarker of cervical cancer that correlates with immune infiltration and promotes malignant behavior

Yue-Chen Zhao, Tie-Jun Wang, Geng-Hui Qu, Li-Zhen She, Jie Cui, Rui-Feng Zhang, Hong-Dao Qu

Abstract read
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  7. SPP1International journal of genomics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue-Chen ZhaoDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.
Tie-Jun WangDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.
Geng-Hui QuDepartment of Radiology, Dongliao County People's Hospital Liaoyuan 136299, Jilin, P. R. China.
Li-Zhen SheDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.
Jie CuiDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.
Rui-Feng ZhangDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.
Hong-Dao QuDepartment of Radiation Oncology, The Second Hospital of Jilin University Changchun 130041, Jilin, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) has become increasingly prevalent in younger women. Tropomyosin 3 (TPM3), a thin filament actin-binding protein, has been implicated in various malignancies. In this study, TPM3 expression was evaluated using RNA-seq data from The Cancer Genome Atlas (TCGA), and its relationship with CESC prognosis was examined with receiver operating characteristic (ROC) curves. The effects of TPM3 on cellular proliferation and migration were examined in CESC cell lines using Cell Counting Kit-8 (CCK-8), colony formation, and Transwell assays, while

Indexed as

cervical neoplasmsDNA methylationepithelial-mesenchymal transitionprognosisTropomyosin 3 (TPM3)tumour microenvironment

Identifiers

PMID37559998
PMCPMC10408471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.