Evidence map›Paper›PMID 37559985›Full record

ArticleAmerican journal of cancer research2023

CHST11-modified chondroitin 4-sulfate as a potential therapeutic target for glioblastoma.

You-Cheng Lin, Yin-Hung Chu, Wen-Chieh Liao, Chia-Hua Chen, Wen-Chuan Hsiao, Ying-Jui Ho, Meng-Yin Yang, Chiung-Hui Liu

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

You-Cheng LinDoctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.
Yin-Hung ChuDoctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.
Wen-Chieh LiaoDoctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.
Chia-Hua ChenMolecular Medicine Research Center, Chang Gung University Taoyuan, Taiwan.
Wen-Chuan HsiaoDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.
Ying-Jui HoDepartment of Psychology, Chung Shan Medical University Taichung, Taiwan.
Meng-Yin YangDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.
Chiung-Hui LiuDoctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant chondroitin sulfate (CS) accumulation in glioblastoma (GBM) tissue has been documented, but the role of excessive CS in GBM progression and whether it can be a druggable target are largely unknown. The aim of this study is to clarify the biological functions of CHST11 in GBM cells, and evaluate therapeutic effects of blocking CHST11-derived chondroitin 4-sulfate (C4S). We investigated the expression of CHST11 in glioma tissue by immunohistochemistry, and analyzed CHST11 associated genes using public RNA sequencing datasets. The effects of CHST11 on aggressive cell behaviors have been studied

Indexed as

C4SCHST11CSPG4glioblastomagliomatherapeutic peptide

Identifiers

PMID37559985
PMCPMC10408464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.